9th SINAPSE Neuro-oncology Imaging Meeting [rescheduled] Mar 11, 2021 09:30 AM - 03:30 PM — West Park Conferencing & Events, 319 Perth Road, Dundee DD2 1NN
Total Body PET 2020 conference [rescheduled] Jun 05, 2021 - Jun 07, 2021 — McEwan Hall, University of Edinburgh
Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke?

Author(s): C. S. Rivers, J. M. Wardlaw

Abstract:
Background and Purpose: In acute ischaemic stroke, the amount (and type) of cellular damage underlying diffusionweighted imaging (DWI) lesion appearances is unclear. We summarized all information from experimental studies of DWI in focal ischaemia models. Methods: We systematically reviewed all published studies of DWI in focal ischaemic stroke models. We extracted key experimental details to determine correlations between histological features and DWI lesion characteristics. Results: Of 141 potentially eligible papers (including more than 2,817 animals, mostly rats), details of key experimental methods were unfortunately often omitted. Consistent findings amongst high-quality studies with blinded analysis included: neuronal damage persists or progresses despite early DWI lesion 'normalisation'; the apparent diffusion coefficient is not very sensitive to the amount of neuronal damage; the 'brighter' the DWI lesion, the greater the neuronal damage; and the DWI lesion may reflect glial more than neuronal changes. Anaesthesia and fixation techniques may inadvertently affect these findings. Conclusions: The relationship between cellular damage and DWI lesion appearance, particularly recovery patterns in reperfusion experiments, remains imprecise. Key experimental details could be reported more completely and consistently. Potential problems from repeated anaesthetics need to be addressed. Early DWI lesion 'recovery' in acute stroke patients may largely reflect glial rather than neuronal 'recovery'. Copyright (C) 2005 S. Karger AG, Basel.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1015-9770
Publication Year: 2005
Periodical: Cerebrovascular Diseases
Periodical Number: 5
Volume: 19
Pages: 328-336
Author Address: