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White matter microstructural abnormalities in euthymic bipolar disorder

Author(s): K. A. N. Macritchie, A. J. Lloyd, M. E. Bastin, K. Vasudev, P. Gallagher, R. Eyre, I. Marshall, J. M. Wardlaw, I. N. Ferrier, P. B. Moore, A. H. Young

Background Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder. Aims To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter. Method Diffusion parameters were measured at several regions in the corpus callosum and in deep/periventricular white matter in 28 currently euthymic patients with bipolar disorder and controls. White matter hyperintensity loads were assessed. Results Comparing the whole data-sets using the sign test, in the group with bipolar disorder, mean diffusivity was greater at all 15 sites (P<0.001) and fractional anisotropy was reduced at 13 (P<0.01). The effect of diagnosis was significant for callosal mean diffusivity and fractional anisotropy and for deep/periventricular mean diffusivity (MANCOVA). Comparing individual regions (Mann-Whitney U-test), prefrontal and periventricular mean diffusivity were significantly increased; callosal and occipital fractional anisotropy were significantly reduced. Former substance use and lithium were possible confounding factors. Periventricular white matter hyperintensities were associated with significantly increased periventricular mean diffusivity in individuals with bipolar disorder. Conclusions Generalised white matter microstructural abnormalities may exist in bipolar disorder, possibly exacerbated by past substance use and ameliorated by lithium.

Full version: Available here

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ISBN: 0007-1250
Publication Year: 2010
Periodical: British Journal of Psychiatry
Periodical Number: 1
Volume: 196
Pages: 52-58
Author Address: Macritchie, KAN Univ British Columbia, Inst Mental Hlth, Dept Psychiat, Suite 430 Strangway Bldg,5950 Univ Blvd, Vancouver, BC V6T 1Z3, Canada Newcastle Univ, Inst Neurosci, Psychobiol Res Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Univ Edinburgh, Med & Radiol Sci & SFC Brain Imaging Res Ctr, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh, Div Clin Neurosci, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh, SFC Brain Imaging Res Ctr, Edinburgh EH8 9YL, Midlothian, Scotland