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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

Author(s): E. O. Aboagye, F. J. Gilbert, I. N. Fleming, A. J. Beer, V. J. Cunningham, P. K. Marsden, D. Visvikis, A. D. Gee, A. M. Groves, L. M. Kenny, G. J. Cook, P. E. Kinahan, M. Myers, L. Clarke

Abstract:
The evaluation of drug pharmacodynamics and early tumour response are integral to current clinical trials of novel cancer therapeutics to explain or predict long term clinical benefit or to confirm dose selection. Tumour vascularity assessment by positron emission tomography could be viewed as a generic pharmacodynamic endpoint or tool for monitoring response to treatment. This review discusses methods for semi-quantitative and quantitative assessment of tumour vascularity. The radioligands and radiotracers range from direct physiological functional tracers like [(15)O]-water to macromolecular probes targeting integrin receptors expressed on neovasculature. Finally we make recommendations on ways to incorporate such measurements of tumour vascularity into early clinical trials of novel therapeutics. Key Points * [ ( 15 ) O]-water is the gold standard for blood flow/tissue perfusion with PET * In some instances dynamic [ ( 18 ) F]-FDG uptake may be used to estimate perfusion * Radiopharmaceuticals that target integrins are now being evaluated for measuring tumour vascularity.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1432-1084 (Electronic) 0938-7994 (Linking)
Publication Year: 2012
Periodical: Eur Radiol
Periodical Number: 7
Volume: 22
Pages: 1465-78
Author Address: Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, MRC Cyclotron Building, Hammersmith Hospital Campus, London, W12 0NN, UK. eric.aboagye@imperial.ac.uk