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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


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Neuroimaging for Research MSc/Dip/Cert

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Online Short Courses

Gender differences of airway dimensions in anatomically matched sites on CT in smokers

Author(s): Y. I. Kim, J. Schroeder, D. Lynch, J. Newell, B. Make, A. Friedlander, R. S. Estepar, N. A. Hanania, G. Washko, J. R. Murphy, C. Wilson, J. E. Hokanson, J. Zach, K. Butterfield, R. P. Bowler, Investigators Copdgene

Abstract:
RATIONALE AND OBJECTIVES: There are limited data on, and controversies regarding gender differences in the airway dimensions of smokers. Multi-detector CT (MDCT) images were analyzed to examine whether gender could explain differences in airway dimensions of anatomically matched airways in smokers. MATERIALS AND METHODS: We used VIDA imaging software to analyze MDCT scans from 2047 smokers (M:F, 1021:1026) from the COPDGene(R) cohort. The airway dimensions were analyzed from segmental to subsubsegmental bronchi. We compared the differences of luminal area, inner diameter, wall thickness, wall area percentage (WA%) for each airway between men and women, and multiple linear regression including covariates (age, gender, body sizes, and other relevant confounding factors) was used to determine the predictors of each airway dimensions. RESULTS: Lumen area, internal diameter and wall thickness were smaller for women than men in all measured airway (18.4 vs 22.5 mm(2) for segmental bronchial lumen area, 10.4 vs 12.5 mm(2) for subsegmental bronchi, 6.5 vs 7.7 mm(2) for subsubsegmental bronchi, respectively p < 0.001). However, women had greater WA% in subsegmental and subsubsegmental bronchi. In multivariate regression, gender remained one of the most significant predictors of WA%, lumen area, inner diameter and wall thickness. CONCLUSION: Women smokers have higher WA%, but lower luminal area, internal diameter and airway thickness in anatomically matched airways as measured by CT scan than do male smokers. This difference may explain, in part, gender differences in the prevalence of COPD and airflow limitation.

Full version: Available here

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ISBN: 1541-2563 (Electronic) 1541-2563 (Linking)
Publication Year: 2011
Periodical: COPD
Periodical Number: 4
Volume: 8
Pages: 285-92
Author Address: Department of Medicine, National Jewish Health, Denver, CO, USA.