PET is Wonderful Annual Meeting 2021 Oct 26, 2021 12:00 AM — Virtual Meeting (online)
NRS Mental Health Network Annual Scientific Meeting 2021 Nov 02, 2021 09:00 AM - 05:00 PM — Royal College of Physicians, Edinburgh (and online)
SRS Autumn Meeting 2021 Nov 12, 2021 08:30 AM - 04:00 PM — Dundee


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis

Author(s): N. J. J. MacDougall, K. W. Muir

Poststroke hyperglycaemia (PSH) is common, has an unclear pathophysiology, and is associated with poor outcomes. Animal studies report conflicting findings. We systematically reviewed the effects of hyperglycaemia on infarct volume in middle cerebral artery occlusion (MCAO) models, generating weighted mean differences between groups using random effects models summarised as effect size (normalised to control group infarct volume as 100%) and 95% confidence interval. Of 72 relevant papers, 23 reported infarct volume. Studies involved 664 animals and 35 distinct comparisons. Hyperglycaemia was induced by either streptozotocin (STZ, 17 comparisons, n = 303) or dextrose (18 comparisons, n = 356). Hyperglycaemic animals had infarcts that were 94% larger, but STZ was associated with significantly greater increase in infarct volumes than dextrose infusion (140% larger versus 48% larger). In seven studies, insulin did not significantly reduce infarct size and results were heterogeneous. Although hyperglycaemia exacerbates infarct volume in MCAO models, studies are heterogeneous, and do not address the common clinical problem of PSH because they have used either the STZ model of type I diabetes or extremely high glucose loads. Insulin had a nonsignificant and significantly heterogeneous effect. Further studies with relevant models may inform clinical trial design. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 807-818; doi:10.1038/jcbfm.2010.210; published online 15 December 2010

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 0271-678X
Publication Year: 2011
Periodical: Journal of Cerebral Blood Flow and Metabolism
Periodical Number: 3
Volume: 31
Pages: 807-818
Author Address: Muir, KW Univ Glasgow, So Gen Hosp, Inst Neurol Sci, Inst Neurosci & Psychol, Glasgow G51 4TF, Lanark, Scotland Univ Glasgow, So Gen Hosp, Inst Neurol Sci, Inst Neurosci & Psychol, Glasgow G51 4TF, Lanark, Scotland