Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England
2021 SINAPSE ASM Sep 16, 2021 - Sep 17, 2021 — Technology & Innovation Centre, University of Strathclyde, 99 George Street, Glasgow
Total Body PET 2021 conference [rescheduled] Sep 22, 2021 - Sep 24, 2021 — Virtual Meeting (online)
PET is Wonderful Annual Meeting 2021 Oct 26, 2021 12:00 AM — Virtual Meeting (online)


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

Author(s): B. S. Aribisala, S. Wiseman, Z. Morris, M. C. Valdes-Hernandez, N. A. Royle, S. M. Maniega, A. J. Gow, J. Corley, M. E. Bastin, J. Starr, I. J. Deary, J. M. Wardlaw

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634). METHODS: We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling. RESULTS: After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (beta=0.47; P<0.0001); Inflammation was weakly but significantly associated with PVS (beta=0.12; P=0.048), but not with WMH (beta=0.02; P=NS). CONCLUSIONS: Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 1524-4628 (Electronic)0039-2499 (Linking)
Publication Year: 2013
Periodical: Stroke
Periodical Number:
Author Address: From Brain Research Imaging Centre (B.S.A., S.W., Z.M., M.C.V.-H., N.A.R., S.M.M., M.E.B., J.M.W.), Centre for Cognitive Ageing and Cognitive Epidemiology (B.S.A., M.C.V.-H., N.A.R., S.M.M., A.J.G., M.E.B., J.S., I.J.D., J.M.W.), Department of Psychology (J.C., I.J.D.), and Geriatric Medicine Unit (J.S.), University of Edinburgh, Edinburgh, United Kingdom; Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE), Edinburgh, United Kingdom (B.S.A., M.C.V.-H., N.A.R., S.M.M., M.E.B., J.M.W.); Department of Computer Science, Lagos State University, Nigeria (B.S.A.); and Department of Psychology, Heriot-Watt University, United Kingdom (A.J.G.).