Ophthalmic Medical Image Analysis MICCAI 2020 Workshop Oct 08, 2020 12:00 AM — Virtual Meeting (online)
Predictive Intelligence in Medicine MICCAI 2020 Workshop Oct 08, 2020 12:00 AM — Virtual Meeting (online)
PET is Wonderful Annual Meeting 2020 Oct 27, 2020 02:00 PM - 05:40 PM — Virtual Meeting (online)
NRS Mental Health Network Annual Scientific Meeting 2020 Nov 04, 2020 09:00 AM - 05:30 PM — Virtual Meeting (online)

eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation?

Author(s): M. R. Dweck, H. J. Khaw, G. K. Z. Sng, E. L. C. Luo, A. Baird, M. C. Williams, P. Makiello, S. Mirsadraee, N. V. Joshi, E. J. R. van Beek, N. A. Boon, J. H. F. Rudd, D. E. Newby

Abstract:
The pathophysiology of aortic stenosis shares many similarities with atherosclerosis and skeletal bone formation. Using non-invasive imaging, we compared aortic valve calcification and inflammation activity with that measured in atherosclerosis and bone. Positron emission and computed tomography was performed using 18F-sodium fluoride (18F-NaF, calcification) and 18F-fluorodeoxyglucose (18F-FDG, inflammation) in 101 patients with calcific aortic valve disease (81 aortic stenosis and 20 aortic sclerosis). Calcium scores and positron emission tomography tracer activity (tissue-to-background ratio; TBR) were measured in the aortic valve, coronary arteries, thoracic aorta, and bone. Over 90 of the cohort had coexistent calcific atheroma, yet correlations between calcium scores were weak or absent (valve vs. aorta r(2) 0.015, P 0.222; valve vs. coronaries r(2) 0.039, P 0.049) as were associations between calcium scores and bone mineral density (BMD vs. valve r(2) 0.000, P 0.766; vs. aorta r(2) 0.052, P 0.025; vs. coronaries r(2) 0.016, P 0.210). 18F-NaF activity in the valve was 28 higher than in the aorta (TBR: 2.66 0.84 vs. 2.11 0.31, respectively, P 0.001) and correlated more strongly with the severity of aortic stenosis (r(2) 0.419, P 0.001) than 18F-NaF activity outwith the valve (valve vs. aorta r(2) 0.167, P 0.001; valve vs. coronary arteries r(2) 0.174, P 0.001; valve vs. bone r(2) 0.001, P 0.806). In contrast, 18F-FDG activity was lower in the aortic valve than the aortic atheroma (TBR: 1.56 0.21 vs. 1.81 0.24, respectively, P 0.001) and more closely associated with uptake outwith the valve (valve vs. aorta r(2) 0.327, P 0.001). In patients with aortic stenosis, disease activity appears to be determined by local calcific processes within the valve that are distinct from atherosclerosis and skeletal bone metabolism. Trial Registration: ClinicalTrials.gov number: NCT01358513.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 0195-668X
Publication Year: 2013
Periodical: European Heart Journal
Periodical Number: 21
Volume: 34
Pages: 1567-1574
Author Address: Dweck, MR Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland Univ Edinburgh, Clin Res Imaging Ctr, Edinburgh, Midlothian, Scotland Univ Cambridge, Div Cardiovasc Med, Cambridge, England