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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation

Author(s): S. Frau, S. Dall'Angelo, G. L. Baillie, R. A. Ross, M. Pira, C. C. Tseng, P. Lazzari, M. Zanda

A novel class of cannabinoid ligands was synthesized in good overall yields by means of oxime-bio-conjugation between hydroxylamine-functionalized Rimonabant-type pyrazoles and fluoro-deoxy-carbohydrates (D-2-fluoro-deoxy-glucose, FDG, and D-5-fluoro-5-deoxy-ribose, FDR). FDR proved to be superior to FDG for bio-conjugation, as it occurred in milder conditions and at faster rate (rt, 20 min vs. 100 degrees C, 30 min). All of the title compounds showed relatively modest affinity for the CBI receptor (high nanomolar range) and selectivities vs. the CB2. (C) 2013 Elsevier B.V. All rights reserved.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 0022-1139
Publication Year: 2013
Periodical: Journal of Fluorine Chemistry
Periodical Number:
Volume: 152
Pages: 166-172
Author Address: Zanda, M Univ Aberdeen, Kosterlitz Ctr Therapeut, Inst Med Sci, Foresterhill AB25 2ZD, Scotland Univ Aberdeen, Kosterlitz Ctr Therapeut, Inst Med Sci, Foresterhill AB25 2ZD, Scotland Neurosci PharmaNess Scarl, I-09010 Pula, CA, Italy Univ Sassari, Dipartimento Chim & Farm, I-07100 Sassari, SS, Italy CNR ICRM, I-20131 Milan, Italy