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Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia

Author(s): V. B. Gradin, G. Waiter, A. O'Connor, L. Romaniuk, C. Stickle, K. Matthews, J. Hall, J. D. Steele

Abstract:
Theories of schizophrenia propose that abnormal functioning of the neural reward system is linked to negative and psychotic symptoms, by disruption of reward processing and promotion of context-independent false associations. Recently, it has been argued that an insula-anterior cingulate cortex (ACC) salience network system enables switching of brain states from the default mode to a task-related activity mode. Abnormal interaction between the insula-ACC system and reward processing regions may help explain abnormal reinforcer processing and symptoms. Here we use functional magnetic resonance imaging to assess the neural correlates of reward processing in schizophrenia. Furthermore, we investigated functional connectivity between the dopaminergic midbrain, a key region for the processing of reinforcers, and other brain regions. In response to rewards, controls activated task related regions (striatum, amygdala/hippocampus and midbrain) and the insula-ACC salience network. Patients similarly activated the insula-ACC salience network system but failed to activate task related regions. Reduced functional connectivity between the midbrain and the insula was found in schizophrenia, with the extent of this abnormality correlating with increased psychotic symptoms. The findings support the notion that reward processing is abnormal in schizophrenia and highlight the potential role of abnormal interactions between the insula-ACC salience network and reward regions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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ISBN: 0925-4927
Publication Year: 2013
Periodical: Psychiatry Research-Neuroimaging
Periodical Number: 2
Volume: 211
Pages: 104-111
Author Address: Gradin, VB Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Div Neurosci, Mailbox 5, Dundee DD1 9SY, Scotland Univ Dundee, Med Res Inst, Dundee DD1 9SY, Scotland Univ Aberdeen, Biomed Imaging Ctr, Aberdeen, Scotland Univ St Andrews, Dept Psychol, St Andrews, Fife, Scotland Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland Royal Cornhill Hosp, Aberdeen, Scotland