SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Molecular insights into bacteroid development during Rhizobium-legume symbiosis

Author(s): A. F. Haag, M. F. F. Arnold, K. K. Myka, B. Kerscher, S. Dall'Angelo, M. Zanda, P. Mergaert, G. P. Ferguson

Rhizobial soil bacteria can form a symbiosis with legumes in which the bacteria fix atmospheric nitrogen into ammonia that can be utilized by the host. The plant, in turn, supplies the rhizobia with a carbon source. After infecting the host cell, the bacteria differentiate into a distinct bacteroid form, which is able to fix nitrogen. The bacterial BacA protein is essential for bacteroid differentiation in legumes producing nodule-specific cysteine-rich peptides (NCRs), which induce the terminal differentiation of the bacteria into bacteroids. NCRs are antimicrobial peptides similar to mammalian defensins, which are important for the eukaryotic response to invading pathogens. The BacA protein is essential for rhizobia to survive the NCR peptide challenge. Similarities in the lifestyle of intracellular pathogenic bacteria suggest that host factors might also be important for inducing chronic infections associated with Brucella abortus and Mycobacterium tuberculosis. Moreover, rhizobial lipopolysaccharide is modified with an unusual fatty acid, which plays an important role in protecting the bacteria from environmental stresses. Mutants defective in the biosynthesis of this fatty acid display bacteroid development defects within the nodule. In this review, we will focus on these key components, which affect rhizobial bacteroid development and survival.

Full version: Available here

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ISBN: 0168-6445
Publication Year: 2013
Periodical: Fems Microbiology Reviews
Periodical Number: 3
Volume: 37
Pages: 364-383
Author Address: Haag, AF Novartis, Vaccines & Diagnost, Via Fiorentina 1, I-53100 Siena, Italy Univ Aberdeen, Inst Med Sci, Sch Med & Dent, Aberdeen, Scotland Univ Aberdeen, Inst Med Sci, Sch Med Sci, Aberdeen, Scotland CNR, Ist Chim Riconoscimento Mol, I-20133 Milan, Italy CNRS, Inst Sci Vegetal, Gif Sur Yvette, France