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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

On the prediction of monocyte deposition in abdominal aortic aneurysms using computational fluid dynamics

Author(s): D. Hardman, B. J. Doyle, S. I. K. Semple, J. M. J. Richards, D. E. Newby, W. J. Easson, P. R. Hoskins

In abdominal aortic aneurysm disease, the aortic wall is exposed to intense biological activity involving inflammation and matrix metalloproteinase-mediated degradation of the extracellular matrix. These processes are orchestrated by monocytes and rather than affecting the aorta uniformly, damage and weaken focal areas of the wall leaving it vulnerable to rupture. This study attempts to model numerically the deposition of monocytes using large eddy simulation, discrete phase modelling and near-wall particle residence time. The model was first applied to idealised aneurysms and then to three patient-specific lumen geometries using three-component inlet velocities derived from phase-contrast magnetic resonance imaging. The use of a novel, variable wall shear stress-limiter based on previous experimental data significantly improved the results. Simulations identified a critical diameter (1.8 times the inlet diameter) beyond which significant monocyte deposition is expected to occur. Monocyte adhesion occurred proximally in smaller abdominal aortic aneurysms and distally as the sac expands. The near-wall particle residence time observed in each of the patient-specific models was markedly different. Discrete hotspots of monocyte residence time were detected, suggesting that the monocyte infiltration responsible for the breakdown of the abdominal aortic aneurysm wall occurs heterogeneously. Peak monocyte residence time was found to increase with aneurysm sac size. Further work addressing certain limitations is needed in a larger cohort to determine clinical significance.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 0954-4119
Publication Year: 2013
Periodical: Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine
Periodical Number: 10
Volume: 227
Pages: 1114-1124
Author Address: Hoskins, PR Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland Univ Western Australia, Sch Mech & Chem Engn, Intelligent Syst Med Lab, Crawley, WA, Australia Univ Edinburgh, Clin Res Imaging Ctr, Edinburgh, Midlothian, Scotland Univ Edinburgh, Ctr Clin & Surg Sci Surg, Edinburgh, Midlothian, Scotland Univ Edinburgh, Inst Mat & Proc, Sch Engn & Elect, Edinburgh, Midlothian, Scotland Univ Limerick, Dept Mech Aeronaut & Biomed Engn, Limerick, Ireland