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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

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Online Short Courses

Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke

Author(s): B. Karaszewski, T. K. Carpenter, R. G. R. Thomas, P. A. Armitage, G. K. S. Lymer, I. Marshall, M. S. Dennis, J. M. Wardlaw

Abstract:
Pyrexia soon after stroke is associated with severe stroke and poor functional outcome. Few studies have assessed brain temperature after stroke in patients, so little is known of its associations with body temperature, stroke severity, or outcome. We measured temperatures in ischemic and normal-appearing brain using H-1-magnetic resonance spectroscopy and its correlations with body (tympanic) temperature measured four-hourly, infarct growth by 5 days, early neurologic (National Institute of Health Stroke Scale, NIHSS) and late functional outcome (death or dependency). Among 40 patients (mean age 73 years, median NIHSS 7, imaged at median 17 hours), temperature in ischemic brain was higher than in normal-appearing brain on admission (38.6 degrees C-core, 37.9 degrees C-contralateral hemisphere, P = 0.03) but both were equally elevated by 5 days; both were higher than tympanic temperature. Ischemic lesion temperature was not associated with NIHSS or 3-month functional outcome; in contrast, higher contralateral normal-appearing brain temperature was associated with worse NIHSS, infarct expansion and poor functional outcome, similar to associations for tympanic temperature. We conclude that brain temperature is higher than body temperature; that elevated temperature in ischemic brain reflects a local tissue response to ischemia, whereas pyrexia reflects the systemic response to stroke, occurs later, and is associated with adverse outcomes.

Full version: Available here

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ISBN: 0271-678X
Publication Year: 2013
Periodical: Journal of Cerebral Blood Flow and Metabolism
Periodical Number: 7
Volume: 33
Pages: 1083-1089
Author Address: Wardlaw, JM Univ Edinburgh, Western Gen Hosp, Div Neuroimaging Sci, Brain Res Imaging Ctr, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, SINAPSE Collaborat, Div Neuroimaging Sci, Brain Res Imaging Ctr, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, Div Clin Neurosci, Edinburgh EH4 2XU, Midlothian, Scotland Med Univ Gdansk, Dept Adult Neurol, Gdansk, Poland Univ Edinburgh, Edinburgh EH4 2XU, Midlothian, Scotland