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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Hypoxia stimulates F-18-Fluorodeoxyglucose uptake in breast cancer cells via Hypoxia inducible Factor-1 and AMP-activated protein kinase

Author(s): T. A. D. Smith, M. Zanda, I. N. Fleming

Abstract:
Introduction: Hypoxia can stimulate F-18-fluorodeoxyglucose (FDG) uptake in cultured cells. A better understanding of the underlying molecular mechanism is required to determine the value of FDG for studying tumour hypoxia. Methods: The effect of hypoxia on FDG uptake, and key proteins involved in glucose transport and glycolysis, was studied in MCF7 and MDA231 breast cancer cell lines. Results: Hypoxia induced a dose- and time-dependent increase in FDG uptake. The FOG increase was transient, suggesting that FDG uptake is only likely to be increased by acute hypoxia (<24 h). Molecular analysis indicated that hypoxia upregulated glut1 and 6-phosphofructo-2-kinase, key proteins involved in regulating glucose transport and glycolysis, and that these changes were induced by Hypoxia-Inducible factor 1 (HIF1) upregulation and/or AMP-activated protein kinase activation. Conclusions: FDG may provide useful information about the oxygenation status of cells in hypoxic regions where HIF1 upregulation is hypoxia-driven. (C) 2013 Elsevier Inc. All rights reserved.

Full version: Available here

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ISBN: 0969-8051
Publication Year: 2013
Periodical: Nuclear Medicine and Biology
Periodical Number: 6
Volume: 40
Pages: 858-864
Author Address: Fleming, IN Aberdeen Biomed Imaging Ctr, Aberdeen AB25 2ZD, Scotland Univ Aberdeen, Sch Med & Dent, Div Appl Med, Aberdeen AB25 2ZD, Scotland Univ Aberdeen, Sch Med Sci, Inst Med Sci, Kosterlitz Ctr Therapeut, Aberdeen AB25 2ZD, Scotland Aberdeen Biomed Imaging Ctr, Aberdeen AB25 2ZD, Scotland