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SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


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Online Short Courses

Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome

Author(s): D. Tarr, D. Graham, L. A. Roy, W. M. Holmes, C. McCabe, I. M. Macrae, K. W. Muir, D. Dewar

Abstract:
Poststroke hyperglycemia is associated with a poor outcome yet clinical management is inadequately informed. We sought to determine whether clinically relevant levels of hyperglycemia exert detrimental effects on the early evolution of focal ischemic brain damage, as determined by magnetic resonance imaging, in normal rats and in those modeling the 'metabolic syndrome'. Wistar Kyoto (WKY) or fructose-fed spontaneously hypertensive stroke-prone (ffSHRSP) rats were randomly allocated to groups for glucose or vehicle administration before permanent middle cerebral artery occlusion. Diffusion-weighted imaging was carried out over the first 4 hours after middle cerebral artery occlusion and lesion volume calculated from apparent diffusion coefficient maps. Infarct volume and immunostaining for markers of oxidative stress were measured in the fixed brain sections at 24 hours. Hyperglycemia rapidly exacerbated early ischemic damage in both WKY and ffSHRSP rats but increased infarct volume only in WKY rats. There was only limited evidence of oxidative stress in hyperglycemic animals. Acute hyperglycemia, at clinically relevant levels, exacerbates early ischemic damage in both normal and metabolic syndrome rats. Management of hyperglycemia may have greatest benefit when performed in the acute phase after stroke in the absence or presence of comorbidities.

Full version: Available here

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ISBN: 0271-678X
Publication Year: 2013
Periodical: Journal of Cerebral Blood Flow and Metabolism
Periodical Number: 10
Volume: 33
Pages: 1556-1563
Author Address: Dewar, D Univ Glasgow, Inst Neurosci & Psychol, Coll Med Vet & Life Sci, Garscube Estate, Glasgow G61 1QH, Lanark, Scotland Univ Glasgow, Inst Neurosci & Psychol, Coll Med Vet & Life Sci, Glasgow G61 1QH, Lanark, Scotland Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci, Glasgow G61 1QH, Lanark, Scotland