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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Imaging Conditioned Fear Circuitry Using Awake Rodent fMRI

Author(s): N. M. Brydges, H. C. Whalley, M. A. Jansen, G. D. Merrifield, E. R. Wood, S. M. Lawrie, S. M. Wynne, M. Day, S. Fleetwood-Walker, D. Steele, I. Marshall, J. Hall, M. C. Holmes

Abstract:
Functional magnetic resonance imaging (fMRI) is a powerful method for exploring emotional and cognitive brain responses in humans. However rodent fMRI has not previously been applied to the analysis of learned behaviour in awake animals, limiting its use as a translational tool. Here we have developed a novel paradigm for studying brain activation in awake rats responding to conditioned stimuli using fMRI. Using this method we show activation of the amygdala and related fear circuitry in response to a fear-conditioned stimulus and demonstrate that the magnitude of fear circuitry activation is increased following early life stress, a rodent model of affective disorders. This technique provides a new translatable method for testing environmental, genetic and pharmacological manipulations on emotional and cognitive processes in awake rodent models.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1932-6203
Publication Year: 2013
Periodical: PLoS One
Periodical Number: 1
Volume: 8
Pages:
Author Address: Holmes, MC Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland Univ Edinburgh, Ctr Cognit & Neural Syst, Edinburgh, Midlothian, Scotland Bristol Myers Squibb Co, Strateg Transact Grp, Wallingford, CT 06492 USA Univ Dundee, Med Res Inst, Dundee, Scotland