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eLearning

SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.


Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699

Author(s): F. Caille, T. J. Morley, A. A. Tavares, C. Papin, N. M. Twardy, D. Alagille, H. S. Lee, R. M. Baldwin, J. P. Seibyl, O. Barret, G. D. Tamagnan

Abstract:
Two new benzodioxane derivatives were synthesized as candidates to image the serotonin 4 receptors by positron emission tomography (PET) and radiolabeled with fluorine-18 via a two-step procedure. Competition binding assays demonstrated that MNI-698 and MNI-699 had sub-nanomolar binding affinities against rat striatal 5-HT4 receptors (Ki of 0.20 and 0.07 nM, respectively). PET imaging in rhesus monkey showed that the regional brain distribution of [(18)F]MNI-698 and [(18)F]MNI-699 were consistent with the known densities of 5-HT4 in brain. [(18)F]MNI-698 and [(18)F]MNI-699 are among the first fluorine-18 radiotracers developed for imaging the 5-HT4 receptors in vivo and are currently under preclinical investigation in primates for future human use.

Full version: Available here

Click the link to go to an external website with the full version of the paper


ISBN: 1464-3405 (Electronic) 0960-894X (Linking)
Publication Year: 2013
Periodical: Bioorg Med Chem Lett
Periodical Number: 23
Volume: 23
Pages: 6243-7
Author Address: Molecular NeuroImaging LLC, New Haven, CT 06510, USA; Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.