UK PET Chemistry Workshop on Radiotracer Dispensing Oct 21, 2022 09:00 AM - 05:00 PM — KCL, London
Scottish Radiotherapy Research Forum Nov 10, 2022 10:00 AM - 04:00 PM — University of Stirling
IPEM Advanced Neuro MRI Nov 15, 2022 09:00 AM - 05:00 PM — Birmingham


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Comparison of fluorodeoxyglucose uptake in symptomatic carotid artery and stable femoral artery plaques

Author(s): S. Shaikh, A. Welch, S. L. Ramalingam, A. Murray, H. M. Wilson, F. McKiddie, J. Brittenden

BACKGROUND: Fluorine-18-labelled fluoroxdeoxyglucose (FDG) positron emission tomography (PET) has been used to evaluate atherosclerotic plaque metabolic activity, and through its uptake by macrophages is believed to have the potential to identify vulnerable plaques. The aims were to compare FDG uptake in carotid plaques from patients who had sustained a recent thromboembolic cerebrovascular event with that in femoral artery plaques from patients with leg ischaemia, and to correlate FDG uptake with the proportion of M1 and M2 macrophages present. METHODS: Consecutive patients who had carotid endarterectomy for symptomatic, significant carotid stenosis and patients with severe leg ischaemia and significant stenosis of the common femoral artery underwent FDG-PET and histological plaque analysis. The voxel with the greatest activity in the region of interest was calculated using the Patlak method over 60 min. Plaques were dual-stained for CD68, and M1 and M2 macrophage subsets. RESULTS: There were 29 carotid and 25 femoral artery plaques for study. The maximum dynamic uptake was similar in carotid compared with femoral plaques: median (range) 9.7 (7.1-12.2) versus 10.0 (7.4-16.6) respectively (P = 0.281). CD68 macrophage counts were significantly increased in carotid compared with femoral plaques (39.5 (33.9-50.1) versus 11.5 (7.7-21.3) respectively; P < 0.001), as was the proportion of M1 proinflammatory macrophages. The degree of carotid stenosis correlated with the maximum dynamic FDG uptake (rs = 0.48, P = 0.008). CONCLUSION: FDG uptake was no greater in symptomatic carotid plaques than in the less inflammatory femoral plaques. In patients on statin therapy. FDG uptake occurred in areas of significant arterial stenosis, irrespective of the degree of inflammation.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 1365-2168 (Electronic) 0007-1323 (Linking)
Publication Year: 2014
Periodical: Br J Surg
Periodical Number: 4
Volume: 101
Pages: 363-70
Author Address: Division of Applied Medicine, University of Aberdeen, Aberdeen Royal Infirmary, Aberdeen, UK.