Scottish Radiological Society Spring Meeting 2021 May 14, 2021 09:00 AM - 05:00 PM — Virtual Meeting (online)
9th Annual Scottish Radiotherapy Research Forum Jun 03, 2021 12:30 PM - 05:00 PM — Virtual Meeting (online)
Medical Imaging Convention [rescheduled] Sep 15, 2021 - Sep 16, 2021 — National Exhibition Centre, Birmingham, England
Total Body PET 2021 conference [rescheduled] Sep 25, 2021 - Sep 27, 2021 — McEwan Hall, University of Edinburgh


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists.

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time

Author(s): F. Wetterling, L. Gallagher, J. Mullin, W. M. Holmes, C. McCabe, I. M. Macrae, A. J. Fagan

Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, multinuclear hydrogen-1/sodium-23 magnetic resonance imaging (MRI) was used to measure the changing sodium signal and hydrogen-apparent diffusion coefficient (ADC) in the ischemic core and penumbra after rat middle cerebral artery occlusion (MCAO). Penumbra and core were defined from perfusion imaging and histologically defined irreversibly damaged tissue. The sodium signal in the core increased linearly with time, whereas the ADC rapidly decreased by >30% within 20 minutes of stroke onset, with very little change thereafter (0.5-6 hours after MCAO). Previous reports suggest that the time point at which tissue sodium signal starts to rise above normal (onset of elevated tissue sodium, OETS) represents stroke onset time (SOT). However, extrapolating core data back in time resulted in a delay of 72+/-24 minutes in OETS compared with actual SOT. At the OETS in the core, penumbra sodium signal was significantly decreased (88+/-6%, P=0.0008), whereas penumbra ADC was not significantly different (92+/-18%, P=0.2) from contralateral tissue. In conclusion, reduced sodium-MRI signal may serve as a viability marker for penumbra detection and can complement hydrogen ADC and perfusion MRI in the time-independent assessment of tissue fate in acute stroke patients.Journal of Cerebral Blood Flow & Metabolism advance online publication, 22 October 2014; doi:10.1038/jcbfm.2014.174.

Full version: Available here

Click the link to go to an external website with the full version of the paper

ISBN: 1559-7016 (Electronic) 0271-678X (Linking)
Publication Year: 2014
Periodical: J Cereb Blood Flow Metab
Periodical Number:
Author Address: Department of Psychiatry, School of Medicine, Trinity College, The University of Dublin, College Green, Dublin, Ireland. Glasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Centre for Advanced Medical Imaging, St James's Hospital/Trinity College Dublin, Dublin, Ireland.