SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**

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Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

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Development of Human Brain Image Banks and Age-Specific Normative Atlases (28th-29th August)

SFC SINAPSE SPIRIT Programme of Knowledge Exchange in Imaging

Resources pack for Brain Image Bank and Brain Atlas Workshop

(see http://tinyurl.com/qzokcfn for updates and links to online abstracts/articles)

Download this resource pack as a Word Document

Session 1: Current and emerging brain image banks and atlases

a) MNI: Alan Evans

  • K Amunts et al, BigBrain: An Ultrahigh-Resolution 3D Human Brain Model Science 2013: Vol. 340 no. 6139 pp. 1472-1475 DOI: 10.1126/science.1235381

b) ENIGMA: Paul Thompson

c) GIN: Bernard Mazoyer

  • 3C study group (2003) Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology 22 :316-325.

  • Dufouil C, Chalmers J, Coskun O, Besancon V, Bousser MG, Guillon P, MacMahon, S, Mazoyer B, Neal B, Woodward M, Tzourio-Mazoyer N, Tzourio C (2005); PROGRESS MRI Substudy Investigators. Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy. Circulation 12:1644-50.

  • Lemaitre H, Crivello F, Grassiot B, Alperovitch A, Tzourio C, Mazoyer B (2005). Age- and sex-related effects on the neuroanatomy of healthy elderly. Neuroimage 26:900-911.

  • Stewart B, Dufouil C, Godin O, Ritchie K, Maillard P, Delcroix N, Crivello F, Mazoyer B, Tzourio C (2008) Neuroimaging correlates of subjective memory deficits in a community population. Neurology 70:1601-1607.

  • Crivello F, Lemaitre H, Dufouil C, Grassiot B, Delcroix N, Tzourio-Mazoyer N, Tzourio C, Mazoyer B (2010). Effects of ApoE-ε4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1,186 healthy elderly persons. Neuroimage 53:1064-1069.

  • Kurth T, Mohamed S, Maillard P, Zhu YC Chabriat H, Mazoyer B, Bousser MG, Dufouil C, Tzourio C (2011) Headache, Migraine, and Structural Brain Lesions and Function: population-based EVA MRI Study. British Medical Journal Jan 18;342:c7357.

  • Stewart B, Godin O, Crivello F, Maillard P, Mazoyer B, Tzourio C, Dufouil C (2011) Longitudinal neuroimaging correlates of subjective memory impairment in a 4-year prospective community study. British Journal of Psychiatry 198:199-205.

  • Tzourio-Mazoyer N, Marie D, Zago L, Perchey G, Leroux G, Mellet E, Jobard G, Joliot M, Crivello F, Petit L, Mazoyer B (2014) Heschl’s gyrification pattern is related to speech listening hemispheric lateralization fMRI investigation in 281 healthy volunteers. Brain Structure and Function (epub March 18)

d) INCF/IMAGEN: Jean-Baptiste Poline

e) OASIS/HCP: Dan Marcus

f) BRAINS: Susan Shenkin

g) EPI2: Rotterdam/Leiden: Aad van der Lugt

  • MA Ikram, A van der Lugt, WJ Neissen, GP Krestin, PJ Koudstaal, A Hofman, MMB Breteler, MW Vernnoij The Rotterdam Scan Study: design and update up to 2012 Eur J Epidemiology (2011) 26: 811-824

h) Rhineland: Monique Breteler

  • http://www.dzne.de/en/research/research-areas/population-studies.html

i) Biobank: Steve Smith

j) UK Dementia Platform: Clare Mackay (see resources in folder, UKDP and MIRIAD slide)

  • http://www.mrc.ac.uk/research/facilities/dementias-research-platform/

k) Perinatal banks: James Boardman

  • Serag A, Aljabar P, Ball G, Counsell SJ, Boardman JP, Rutherford MA, Edwards AD, Hajnal JV, Rueckert D. Construction of a consistent high-definition spatio-temporal atlas of the developing brain using adaptive kernel regression. Neuroimage. 2012 Feb 1;59(3):2255-65

  • Bassi L, Chew A, Merchant N, Ball G, Ramenghi L, Boardman J, Allsop JM, Doria V, Arichi T, Mosca F, Edwards AD, Cowan FM, Rutherford MA, Counsell SJ. Diffusion tensor imaging in preterm infants with punctate white matter lesions. Pediatr Res. 2011 Jun;69(6):561-6.

  • Kuklisova-Murgasova M, Aljabar P, Srinivasan L, Counsell SJ, Doria V, Serag A, Gousias IS, Boardman JP, Rutherford MA, Edwards AD, Hajnal JV, Rueckert D. A dynamic 4D probabilistic atlas of the developing brain. Neuroimage. 2011 Feb 14;54(4):2750-63

Resources from Serena Counsell’s group:

Resources from Petra Hüppi’s group (Lana Vasung):

Session 2 "What is normal?": Alan Evans

Discussion groups:

    1. Minimum image and metadata to define normality (John Ashburner)

    2. How to use existing data, likely gaps (Monique Breteler)

    3. Combining all stages of life in one image bank (James Boardman/Dominic Job)

Session 3 "Legal and ethical issues" Grahame Laurie

Discussion groups:

    1. Consent, industry, international issues (Burkhard Schaefer)

    2. Privacy, anonymisation, levels of access (Hester Ward)

    3. Research tourism, incidental findings (Alison Murray)

Session 4 Multisource 'big' data: "What do we need to use big data" JB Poline

  • JB Poline, JL. Breeze, St Ghosh, KGorgolewski, YO Halchenko, M Hanke, C Haselgrove, K G. Helmer, DB. Keator, DS Marcus, RA Poldrack, Y Schwartz, J Ashburner DN Kennedy - Data sharing in neuroimaging research Front. Neuroinform., 2012 | doi: 10.3389/fninf.2012.00009


Discussion groups:

1) Harmonising data (Aziz Sheikh)

2) Database Infrastructure (Dan Marcus)

3) Data provenance, quality assurance (Albert Burger)

Session 5 Making image databanks work: Steve Smith

1) Atlas creation tools and registration issues (variability) (Bernard Mazoyer)

2) Data sharing/citation/storage (Steve Pavis and David Wyper)

Other general useful resources:

  • G Ziegler, GR Ridgway, R Dahnke, C Gaser, for The Alzheimer's Disease Neuroimaging Initiative Individualized Gaussian process-based prediction and detection of local and global gray matter abnormalities in elderly subjects NeuroImage, Vol 97, 15 August 2014, P 333–348, a Wellcome Trust Center for Neuroimaging, Institute of Neurology, London, UK. DOI: 10.1016/j.neuroimage.2014.04.018

  • MIRIAD: Minimal Interval Resonance Imaging in Alzheimer's Disease (Nick Fox)

46 clinical AD, 23 agematched elderly controls, Longitudinal (up to 12 scans) volumetric MRI scanning on single 1.5T scanner http://www.ucl.ac.uk/drc/research/miriad/Database


Many thanks to our funders whose contributions have made this meeting possible:

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