My interests lie in the development of new technology and methods in MRI to solve problems in bio-medicine. Together with my group I have worked on methods of imaging free radicals by MRI, and on techniques for imaging solid materials with ultra-short T2 relaxation times. In recent years, my research has focussed on fast field-cycling (FFC) MRI , where the magnetic field is switched rapidly during the imaging procedure. In this way, FFC can access contrast mechanisms which are invisible to conventional MRI. My group has built a variety of MRI scanners over the years, including whole-body sized FFC-MRI scanners. We are currently investigating the use of FFC-MRI in a range of biological and medical research applications.
See our research group’s web page at https://www.abdn.ac.uk/research/ffc-mri/
MRI technology and methods. Applications of novel MRI techniques.
Geninatti Crich S., Baroni S., Stefania R., Broche L.M., Senn N., Lurie D.J., Ross P.J. “A novel class of 1H‐MRI Contrast Agents based on the relaxation enhancement induced on water protons by 14N imidazole moieties”, Angew. Chemie, In Press (2020). DOI: 10.1002/anie.202011513
Kruk D., Masiewicz E., Wojciechowski M., Florek-Wojciechowska M., Broche L.M. and Lurie D.J. “Slow dynamics of solid proteins – Nuclear magnetic resonance relaxometry versus dielectric spectroscopy”, J. Magn. Reson. (2020). DOI: 10.1016/j.jmr.2020.106721
Kruk D., Rochowski P., Florek-Wojciechowska M., Sebastião P.J., Lurie D.J., Broche L.M. “1H spin-lattice NMR relaxation in the presence of residual dipolar interactions – Dipolar relaxation enhancement”, J. Magn. Reson. 318 (2020) DOI: 10.1016/j.jmr.2020.106783
Abbas H, Broche L.M., Ezdoglian A., Li D., Yuecel R., Ross P.J., Cheyne L., Wilson H.M., Lurie D.J. and Dawson D.K. “Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept”, J. Magn. Reson. (2020). DOI: 10.1016/j.jmr.2020.106722
Baroni S., Ruggiero M.R., Bitonto V., Broche L.M., Lurie D.J., Aime S., Geninatti Crich S. “In vivo assessment of tumour associated macrophages in murine melanoma obtained by low-field relaxometry in the presence of iron oxide particles”, Biomaterials (2020). DOI: 10.1016/j.biomaterials.2020.119805.
Kruk D., Masiewicz E., Borkowska A.M., Rochowski P., Fries P.H., Broche L.M. and Lurie D.J. “Dynamics of Solid Proteins by Means of Nuclear Magnetic Resonance Relaxometry”, Biomolecules, 9, 652 (2019). DOI: 10.3390/biom9110652.
Kruk D., Rochowski P., Masiewicz E., Wilczynski S., Wojciechowski M., Broche L.M. and Lurie D.J. “Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry”, ChemPhysChem, 20, 2816 (2019). DOI: 10.1002/cphc.201900761.
Broche L.M., Ross P.J., Davies G.R., MacLeod M.-J. and Lurie D.J. “A whole-body Fast Field-Cycling scanner for clinical molecular imaging studies”, Scientific Reports, 9:10402 (2019). DOI: 10.1038/s41598-019-46648-0
Bödenler M., de Rochefort L., Ross P.J., Chanet N., Guillot G., Davies G.R, Gösweiner C., Scharfetter H., Lurie D.J. and Broche L.M. “Comparison of fast field-cycling magnetic resonance imaging methods and future perspectives”, Molecular Physics, 117, 832-848 (2018). DOI: 10.1080/00268976.2018.1557349
Lurie D.J., Ross P.J. and Broche L.M. “Techniques and Applications of Field-cycling Magnetic Resonance in Medicine”, in: “Field-cycling NMR Relaxometry: Instrumentation, Model Theories and Applications”; New Developments in NMR No. 18, Kimmich R., ed., Royal Society of Chemistry, UK, pp 358-384 (2018). DOI: 10.1039/9781788012966
Kishimoto S., Cherukiri M.K., Khramtsov V.V., Utsumi H. and Lurie D.J. “In vivo Application of Proton Electron Double Resonance Imaging”, Antioxidants & Redox Signaling, 28, 1345-1364 (2018). DOI: 10.1089/ars.2017.7341
Zampetoulas V., Lurie D.J. and Broche L.M. “Correction of Environmental Magnetic Fields for the Acquisition of Nuclear Magnetic Relaxation Dispersion Profiles Below Earth’s Field”, J. Magn. Reson., 282, 38-46 (2017). DOI: 10.1016/j.jmr.2017.07.008
Broche L.M., Ross P.J., Davies G.R. and Lurie D.J. “Simple algorithm for the correction of MRI image artefacts due to random phase fluctuations”, Magn. Reson. Imaging, 44, 55-59 (2017). DOI: 10.1016/j.mri.2017.07.023
Ross P.J., Broche L.M. and Lurie D.J. “Rapid Field-Cycling MRI using Fast Spin-Echo”, Magn. Reson. Med., 73, 1120 (2015). DOI: 10.1002/mrm.25233
Pine K.J., Goldie F. and Lurie D.J. “In vivo field-cycling relaxometry using an insert coil for magnetic field offset”, Magn. Reson. Med. 72, 1492-1497 (2014). DOI: 10.1002/mrm.25040
Mitchell J., Broche L.M., Chandrasekera T.C., Lurie D.J. and Gladden L.F. “Exploring Surface Interactions in Catalysts using Low Field Nuclear Magnetic Resonance”, J. Phys. Chem. C, 117, 17699−17706 (2013). DOI: 10.1021/jp405987m
Broche L.M., Ashcroft G.P. and Lurie D.J. “Detection of osteoarthritis in knee and hip joints by FFC NMR”, Magn. Reson. Med., 68, 358-362 (2012). DOI: 10.1002/mrm.23266
Lurie D.J., Aime S., Baroni S., Booth N.A., Broche L.M., Choi C.-H., Davies G.R., Ismail S., Ó hÓgáin D. and Pine K.J. “Fast Field-Cycling Magnetic Resonance Imaging”, Comptes Rendus Physique 11, 136-148 (2010). DOI: 10.1016/j.crhy.2010.06.012