E. Calamai, S. Dall'Angelo, D. Koss, J. Domarkas, T. J. McCarthy, M. Mingarelli, G. Riedel, L. F. Schweiger, A. Welch, B. Platt, M. Zanda
1364-548X (Electronic)1359-7345 (Linking)
Chem Commun (Camb)
Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK.
Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [(18)F], was synthesised in radiofluorinated form. PET/CT Imaging with [(18)F] identified beta-amyloid over-expressing transgenic mice (betaA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label betaA plaques in brain sections of betaA mice, and co-localise with a fluorescent Zn(II) indicator.