Upcoming Events

Molecular Imaging Workshop 2017 Nov 20, 2017 - Nov 23, 2017 — San Sebastian, Spain
TOPIM ("hot TOPics in IMaging") 2018: Imaging Metabolism Jan 21, 2018 - Jan 26, 2018 — L'Ecole de Physique des Houches, France
SINAPSE Molecular Imaging PET/SPECT focus group meeting Feb 05, 2018 10:30 AM - 04:00 PM — Carnegie Lecture Theatre (C3-05), Joseph Black Building, School of Chemistry, University of Glasgow
'Let's Talk About Health' free public lecture Feb 21, 2018 05:30 PM - 06:30 PM — Wellcome Auditorium, Queen’s Medical Research Institute, University of Edinburgh

Dr Adriana Tavares

Position: Head of Preclinical PET/CT, EPI

Interests:

PET and SPECT imaging

Institute: Edinburgh Preclinical Imaging

Department:


Research Themes

1. Development of novel radiotracers for PET and SPECT imaging

2. Use of preclinical PET/CT for characterization of animal models and drug discovery

Key Publications

2015

1. Blair A, Zmuda F, Malviya G, Tavares AAS, Tamagnan GD, Chalmers AJ, Dewar D, Pimlott SL, Sutherland A (2015). A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chem Sci. 6:4772-4777

2. Liberal FDCG, Tavares AAS, Tavares JMR (2015). Comparative analysis of eleven different radioisotopes for palliative treatment of bone metastases by computational methods. Med Phys. 41:114101 

2014

1. Tavares AAS, Caillé F, Barret O, Papin C, Lee H, Morley T, Fowles K, Holden D, Seibyl JP, Alagille D, Tamagnan GD (2014). In vivo evaluation of 18F-MNI-698: A novel 18F-labeled radiotracer for imaging of serotonin 4 receptors in brain. J Nuc Med. 55: 858-64

2. Tavares AAS, Caillé F, Barret O, Papin C, Lee H, Morley T, Fowles K, Holden D, Seibyl JP, Alagille D, Tamagnan GD (2014). Whole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain: [18F]MNI-698. Nuc Med Biol. 41: 432-9

3. Tavares A, Barret O, Alagille D, Morley T, Papin C, Maguire RP, Briard E, Auberson Y, Tamagnan G (2014). Brain Distribution of MS565, an Imaging Analogue of Siponimod (BAF312), in Non-human Primates. Neurology. 82: Supp. P1.168

4. Tavares A, Becker G, Barret O, Morley T, Alagille D, Vacher B, Newman-Tancredi A, Tamagnan G, Zimmer L (2013). Initial evaluation of [18F]F13714, a novel 5-HT1A receptor agonist in non-human primates. Eur J Nuc Med Mol Imag. 40(S2):S144

5. Barret O, Thomae D, Tavares AAS, Alagille D, Papin C, Waterhouse R, McCarthy T, Jennings D, Marek K, Russell D, Seibyl J, Tamagnan GD (2014). In vivo assessment and dosimetry of two novel PDE10A positron emission tomography radiotracers in human: 18F-MNI-659 and 18F-MNI-654. J Nuc Med. 55: 1297-1304

6. Barret O, Hannestad J, Alagille D, Vala C, Tavares AAS, Papin C, Morley T, Lee H, Seibyl J, Tytgat D, Laruelle M, Tamagnan G (2014). Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys. J Nuc Med. 55: 1712-8

7. Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJA, Tavares AAS, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2014). Amyloid imaging with [11C]PIB positron emission tomography for traumatic brain injury. JAMA Neurol. doi:10.1001/jamaneurol.2013.4847

8. Alagille D, Barret O, Vala C, Caille F, Papin C, Morley T, Lee S, Tavares A, Seibyl J, Tamagnan G (2013). Preclinical evaluation of [F-18]MNI-444. A promising PET imaging agent of adenosine A(2a) receptors. J Labelled Comp Radiopharm. 56(S1):S308

9. Alagille D, Barret O, Caille F, Morisset-Lopez S, Bojarski AJ, Finaru AL, Suzenet F, Guillaumet G, Papin C, Morley T, Lee S, Tavares A, Seibyl J, Tamagnan G (2013). Evaluation of [F-18]MNI-709 and [F-18]MNI-711 as potential 5HT(7) PET imaging agents. J Labelled Comp Radiopharm. 56(S1):S309

10. Tamagnan G, Tavares A, Barret O, Alagille D, Seibyl J, Marek K, Maguire PR, Briard E, Schmouder R, Behrje R, Jennings D (2012). Brain distribution of BZM055, and analogue of fingolimod (FTY720), in human. Mult Scler. 18(S4):102.

2013

1. Tavares AAS, Batis JC, Papin C, Jennings D, Alagille D, Russell DS, Vala C, Lee H, Baldwin RM, Zubal IG, Marek KL, Seibyl JP, Barret O and Tamagnan GD (2013). Kinetic modeling, test-retest and dosimetry of [123I]MNI-420 in humans. J Nuc Med. 54:1760-1767

2. Tavares AAS, Batis J, Barret O, Alagille D, Vala C, Kudej G, Koren A, Cosgrove K, Nice K, Kordower J, Seibyl J, Tamagnan G (2013). In vivo evaluation of [123I]MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain. Nuc Med and Biol. 40:403-409

3. Tavares AAS, Barret O, Batis J, Alagille D, Koren A, Papin C, Kudej G, Nice K, Kordower J, Cosgrove K, Kloczynski T, Brenner E, Seibyl J, Tamagnan G (2013). Kinetic modelling and occupancy measures of the norepinephrine transporters in baboons using Single Photon Emission Computed Tomography with 123I-INER. Synapse. 67:30-41

4. Caillé F, Morley T, Tavares AAS, Papin C, Twardy NM, Alagille D, Lee HS, Baldwin RM, Seibyl JP, Barret O, Tamagnan GD (2013). Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699. Bioorganic Med Chem Lett. 23:6243–6247

2012

1. Tavares AAS, Jobson NK, Dewar D, Sutherland A, Pimlott S, Batis J, Barret O, Seibyl J, Tamagnan G (2012). Iodine-123 Labeled Reboxetine Analogues for Imaging of Noradrenaline Transporter in Brain Using Single Photon Emission Computed Tomography. Synapse. 66:923-930.

2. Tavares AAS and Tavares JMRS (2012). Computational Modelling of Cellular Effects Post-Irradiation with Low- and High-Let Particles and Different Absorbed Doses. Dose-Response. DOI: 10.2203/dose-response.11-049.Tavares

3. Tavares AAS, Lewsey J, Dewar D, Pimlott S (2012). Relationships between radiotracer properties determined by high performance liquid chromatography and in vivo measurements in human brain. Nuc Med and Biol. 39:127-135.

2011

1. Tavares AAS, Jobson NK, Dewar D, Sutherland A, Pimlott S (2011). Development of the radiosynthesis of high-specific-activity 123I-NKJ64. Nuc Med and Biol. 38:493-500.

2. Tavares AAS, Jobson NK, Dewar D, Sutherland A, Pimlott S (2011). 123I-NKJ64: A Novel SPECT Radiotracer for Imaging the Noradrenaline Transporter in Brain. Synapse. 65:658–667.

3. Tavares AAS and Tavares JMRS (2011). 99mTc Auger electrons – Analysis on the effects of low absorbed doses by computational methods. Appl Radiat Isot. 69:607-608

2010

1. Tavares AAS and Tavares JMRS (2010). Evaluating 99mTc Auger Electrons for Targeted Tumor Radiotherapy by Computational Methods. Med Phys. 37(7):3551-3559

2. Tavares AAS and Tavares JMRS (2010). 99mTc Auger Electrons for Targeted Tumour Therapy: A Review. Int J Radiat Biol. 86(4):261-270.

3. Stevenson L, Tavares AAS, Brunet A, McGonagle FI, Dewar D, Pimlott SL, Sutherland A (2010). New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein. Bioorganic Med Chem Lett. 20, 954-957.


Collaborators

University of Glasgow, Scotland

University of Porto, Portugal

Software Expertise

Image acquisition/analysis:

- PMOD Software

- vivoQuant

- Hermes Medical Software

- Acquisition and analysis software from different PET/SPECT scanners, including, GE, Siemens, Phillips and Mediso

Simulation and dosimetry software:

- Monte Carlo Damage Simulation (MCDS)

- Monte Carlo Excision Repair (MCER)

- VC Radiobiology Software

- OLINDA/EXM 1.0 Software