Upcoming Events

'The developing human brain' public lecture Feb 25, 2019 05:30 PM - 06:30 PM — Chancellor's Building, Edinburgh, EH16 4SB
ISMRM Workshop on MR Value Mar 11, 2019 - Mar 13, 2019 — University of Edinburgh
European Molecular Imaging Meeting 2019 Mar 19, 2019 - Mar 22, 2019 — Scottish Event Campus, Glasgow
Edinburgh SPM Course 2019 Apr 01, 2019 - Apr 05, 2019 — University of Edinburgh
Health Innovation and Technologies Research Festival Apr 01, 2019 - Apr 02, 2019 — James Watt Centre, Heriot-Watt University, Edinburgh

Professor Douglas Steele

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Position: Clinial Professor of NeuroImaging, Honorary Consultant Psychiatrist

Interests:

Psychiatry, neurology, brain imaging: http://dslink333.dyndns.org/

 

 

    Institute: University of Dundee

    Department: School of Medicine (Neuroscience)


    Research Themes

    My main clinical and academic interests are psychiatryneurology and its overlap neuropsychiatry, linked to neuroimaging and machine learning. Two main areas:

    iMachine learning for individual patient predictions – diagnostic and prognostic.  Initial work focused on proof of concept studies using research data, now focused on application to routinely acquired NHS data, with a particular emphasis on fully integrating the techniques into routine clinical practice.  Recent success in obtaining MRC Programme Grant funding.

    ii) Mechanisms research, which include computational modelling of behaviour and brain function (model-based fMRI, forward translation), neurosurgical studies on therapeutic interventions for brain disorders and back translation from functional brain imaging studies on patients to animals for drug discovery.

    Techniques: structured psychiatric clinical assessment, neuropsychological testing, reinforcement learning and neuroeconomics paradigms, Matlab programming, fMRI, GABA spectroscopy, computational modelling of brain and behaviour, diffusion tensor imaging, machine learning, PET and EEG source reconstruction.

    Key Publications

    Up to date list

    Selected Publications:

    Tolomeo, S., Christmas, D., Jentzsch, I., Johnston, B., Sprenglemeyer, R., Matthews, K., Steele, J.D. (2016) “A Causal Role for the Anterior Mid-Cingulate Cortex in Negative Affect and Cognitive Control”  Brain (in press)

    Johnston, B.A.., Tolomeo, S, Gradin, V., Christmas, D., Matthews, K., Steele J.D. (2015) “Failure of Hippocampal Deactivation during Loss Events in Treatment-Resistant Depression” Brain138(9) 2766-76

    Gradin V., Baldacchino A., Balfour D., Matthews K, Steele J.D. (2014) “Abnormal Brain Activity during a Reward and Loss Task in Opiate Dependent Patients receiving Methadone Maintenance Therapy” Neuropsychopharmacology 39(4):885-94

    Mwangi, B., Ebmeier K.P., Matthews, K.M., Steele, J.D. (2012) "Multicentre Diagnostic Classification of Individual Structural Neuroimaging Scans from Patients with Major Depressive Disorder", Brain 135(1) 1508-21

    Perrin, J., Merz, S., Bennett, D.., Currie, J., Steele J.D., Reid I., Schwarzbauer C. (2012) "Electroconvulsive Therapy Reduces Frontal Connectivity in Severe Depression", Proc Natl Acad Sci USA 109(14) 5464-8

    Gradin, V., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., Reid, I., Hall, J., Steele, J.D. (2011) "Expected Value and Prediction Error Abnormalities in Depression and Schizophrenia", Brain 134(6) 1751-1764

    Kumar P, Waiter G, Ahearn T, Milders M, Reid I, Steele J.D. (2008) “Abnormal temporal difference reward-learning signals in major depression” Brain, 131(8) 2084-2093

    Rück C, Karlsson A, Steele J.D., Edman G, Meyerson B.A., Ericson K, Nyman H, Åsberg M, Svanborg P (2008) "Capsulotomy for Obsessive-Compulsive Disorder – long-term follow-up of 25 patients" JAMA Psychiatry, 65(8), 914-921

    Steele J.D., Christmas D., Eljamel M.S., Matthews K. (2008) “Anterior cingulotomy for major depression: Clinical outcome and relationship to lesion characteristics” Biological Psychiatry, 63(7), 670-677

    Steele J.D., Kumar P., Ebmeier, K.P. (2007) “Blunted response to feedback information in depressive illness”, Brain, 130 (9), 2367-74

    Ebmeier K., Donaghey C., Steele J.D. (2006) “Recent Developments and Current Controversies in Depression”, Lancet, 367, 153-167

    Steele J.D., Meyer M., Ebmeier K.P. (2004) “Neural Predictive Error Signal Correlates with Depressive Illness Severity in a Game Paradigm” NeuroImage, 23, 269-280


    Collaborators

    Universities of Edinburgh, Glasgow, St Andrews, Aberdeen, UCL and NHS

     

     


    Software Expertise

    Machine learning, Matlab programming, SPM analyses, Computational modelling of behaviour and brain function