Dr William Holmes

I am interested in all aspects of Magnetic Resonance, with emphasis on pre-clinical research. My research interests focus on the development and application of novel MR methods in both the physical and biomedical sciences.
Pre-clinical magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI). Development of diagnostic and therapeutic techniques in stroke. Pre-clinical therapeutic agents in oncology. Novel cardiac imaging methods. Application of MRI /MRS in the physical sciences and engineering.
-
Holmes WM, Lopez-Gonzalez MR, Gallagher L, Deuchar GA, Macrae IM, Santosh C. Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. NMR in Biomedicine. 2012. 25: 295-304.
-
Baskerville TA, McCabe C, Mullin J, Carberry L, Macrae IM, Holmes WM. Non-invasive MRI measurement of CBF: validating an arterial spin labelling sequence with 99mTc-HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism. 2012. 32: 973-977.
-
Ruest T, Holmes WM, Barrie JA, Griffiths IR, Anderson TJ, Dewar D , Edgar JM. High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus–Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine. 2011. 24: 1369-1379.
-
Dani KA, Santosh C, Brennan D, McCabe C, Holmes WM, Condon B, Hadley DM, Macrae IM, Shaw M & Muir KW (2010). T2* Weighted Magnetic Resonance Imaging with Hyperoxia in Acute Ischemic Stroke. Annals of Neurology. 2010. 68(1) : 37-47.
-
Holmes WM, McCabe C, Mullin JM, Condon B, Bain MM “Non-Invasive Self-Gated MR Cardiac Imaging of Developing Chick Embryos In-Ovo.” CIRCULATION. 117, E346-347, 2008.
-
M.R. Lopez, W.M. Holmes, P.T. Callaghan and P.J. Photinos. " Shear banding fluctuation and nematic order in wormlike micelles". Physical Reveiw Letters. 93, 268302. Dec 2004.