Upcoming Events

ERASMUS Course on MRI: Basic MRI Physics Sep 25, 2017 - Sep 29, 2017 — Ninewells Hospital Medical School, Dundee
7th SINAPSE-SANON Meeting Sep 28, 2017 09:30 AM - 04:00 PM — Wellcome Rooms, Royal Society of Edinburgh, 22-26 George Street, Edinburgh
ECCOMAS VipIMAGE 2017 Oct 18, 2017 - Oct 20, 2017 — Porto, Portugal
ESMRMB 2017 Congress Oct 19, 2017 - Oct 21, 2017 — Fira de Barcelona, Barcelona, Spain
NRS Mental Health Network Annual Scientific Meeting Oct 25, 2017 09:00 AM - 05:00 PM — Teaching & Learning Centre, Queen Elizabeth University Hospital Glasgow

Dr Sally Pimlott

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Position: Head of Radiopharmacy R&D

Interests:

Dr Pimlott is the principal radiochemist in the research and development radiopharmaceutical group, based at the Radionuclide Dispensary, Western Infirmary, Glasgow. Her research is focused on the development of novel molecular imaging agents. This includes:-

  • the development of novel radiolabelling methodologies
  • the synthesis and evaluation of novel tracer candidates using both in vitro and in vivo imaging techniques
  • the development of novel in vitro methodologies for the prediction of radiotracer in vivo characteristics.

Dr Pimlott is also experienced in the provision of radiopharmaceuticals for clinical research studies in compliance with Good Manufacturing Practice standards. Research is funded by the SINAPSE, Wellbeing of Women, Translational Medicine Research Collaboration (TMRC), Neurosciences Foundation, Chief Scientist Office (Scottish Executive), Medical Research Scotland and GE Healthcare.

Institute: Greater Glasgow and Clyde NHS

Department: Department of Clinical Physics


Research Themes

Molecular Imaging Tracer Development Radiochemistry

Key Publications
  • Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans. Krishnadas R, Nicol A, Sassarini J, Puri N, Burden AD, Leman J, Combet E, Pimlott S, Hadley D, McInnes IB, Cavanagh J. Brain, Behavior, and Immunity Available online 6 August 2015
  • A novel 18F-labelled high affinity translocator protein agent for PET imaging. Blair A,Zmuda F, Malviya G, Chalmers AJ, Dewar D, Pimlott SL, Sutherland A. Chemical Science (2015) 6 4772-4777
  • Assessment of [¹²⁵I]WYE-230949 as a novel histamine H₃ receptor radiopharmaceutical. Lewis DY, Champion S, Wyper D, Dewar D, Pimlott S. PLoS ONE (2014) 9(12): e115876
  • Radioisotopes for Medical Imaging. Pimlott SL. International Journal of Modern Physics A (2014) 29 1441003
  • Targeting mTOR Dependency in Pancreatic Cancer. Morran DC, Wu J, Jamieson NB, Mrowinska A, Kalna G, Karim SA, Au AYM, Scarlett CJ, Chang DK, Pajak MZ,  Owen KA, McKay CJ, Carter CR, Gillen G, Champion S, Pimlott SL, Anderson K, Evans  TRJ, Grimmond SM, Biankin AV, Sansom OJ, Morton JP. Gut (2014). 63:1481–1489.
  • Venlafaxine alters microvascular perfusion, [123I]beta-CIT binding and BDI scores in flushing postmenopausal women. Sassarini J, Krishnadas R, Cavanagh J, Nicol A,Pimlott SL, Ferrell W, Lumsden MA. Maturitas. (2014) 77 267-273.
  • Amyloid imaging with [11C]PIB in traumatic brain injury. Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJA, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP,  Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK. JAMA Neurology (2014) 71:23-31
  • Structure-activity relationships of novel iodinated quinoline-2-carboxamides for targeting the translocator protein, Blair A, Stevenson L, Dewar D, Pimlott SL and Sutherland A. Med Chem Commun (2013) 4: 1461-1466
  • Nickel-Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Entry to Tracers for SPECT Imaging. Cant AA, Champion S, Bhalla R, Pimlott SL and Sutherland A. Angewandte Chemie International Edition (2013) 52: 7829-7832
  • Iodine-123 labelled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography. Tavares AAS, Jobson NK, Dewar D, Sutherland A, Pimlott SL, Batis J, Barret O, Seibyl J, Tamagnan G. Synapse (2012) 66:923-930.
  • Biodistribution and dosimetry of 123I-mZIENT: a novel ligand for imaging serotonin transporters. Nicol A, Krishnadas R, Champion S, Tamagnan G, Stehouwer JS, Goodman MM, Hadley DM, Pimlott S. Eur J Nucl Med Mol Imaging. (2012) 39: 786-791
  • Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides. Cant AA, Bhalla R, Pimlott SL, Sutherland A. Chem Comm. (2012) 48: 3993-3995
  • Radiotracer properties determined by high performance liquid chromatography: a potential tool for brain radiotracer discovery. Tavares AAS, Lewsey J, Dewar D, Pimlott SL. Nuc Med Biol. (2012) 39:127-135
  • Radiosynthesis of 123I-labelled benzimidazoles as novel SPECT tracers for the Histamine H3 receptor. Champion S, Gross J, Robichaud AJ, Pimlott S. Journal of Labelled Compounds and Radiopharmaceuticals. (2011) 54:674-677
  • Development of the Radiosynthesis of High Specific Activity 123I-NKJ64. Tavares AAS, Jobson NK, Dewar D, Sutherland A, Pimlott SL. Nuc Med Biol. (2011) 38:493-500
  • 123I-NKJ64: A Novel SPECT Radiotracer for Imaging the Noradrenaline Transporter in Brain. Tavares AAS, Jobson NK, Dewar D, Sutherland A, Pimlott SL. Synapse. (2011) 65:658-667
  • Molecular tracers for the PET and SPECT imaging of disease. Pimlott SL and Sutherland A. Chem Soc Rev. (2011) 40:149-162.
  • Alterations in nicotinic alpha4beta2 receptor binding in vascular dementia using (123)I-5IA-85380 SPECT: Comparison with regional cerebral blood flow. Colloby SJ, Firbank MJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED, O'Brien JT. Neuorbiol Aging. (2011) 32: 293-301

Collaborators

Aberdeen Biomedical Imaging Centre - Prof F Gilbert and colleagues Scotland

Clinical Research Imaging Centre (CRIC) - Prof D Newby and colleagues Scotland

Prof M Bradley, University of Edinburgh, Scotland

Prof K Ebmeier, University of Oxford United Kingdom

Translational Medical Research Council Scotland

Prof A Spivey, University College London United Kingdom

Dr R Krisnadas, University of Glasgow Scotland

Dr A Sutherland, University of Glasgow Scotland

Prof M Lumsden, University of Glasgow Scotland

Dr E Newman, University of Glasgow Scotland

Dr G Tamagnan and colleagues, Molecular Neuroimaging Ltd and Yale University, USA Scotland

Prof O Samson, Beatson Institute for Cancer Research Scotland

Prof T Evan, Beatson Institute for Cancer Research Scotland

Dr D Dewar, University of Glasgow Scotland

Dr J Cavanagh, University of Glasgow Scotland

Dr M Goodman and colleagues, Emory University, Atlanta, GA, USA International

Dr Jos Eersals and colleagues, VU university, Amsterdam, The Netherlands International

Molecular Insight Pharmaceuticals, Cambridge, MA, USA International

GE Healthcare, Medical Diagnostics International