Organisation:
Department:
Interests:
Development, validation and translation of novel imaging biomarkers in brain disease
My research programme aims at streamlining imaging biomarkers to the clinics by methodically addressing the challenges at the interface between on one side MRI physics & imaging and on the other biology & medicine. My work lies at the intersection of these fields, covering the development of novel MRI modalities and applied biomarkers, and the systematic validation of both the MRI measure and the biomarker.
Research Themes:
Research fields:
• Magnetic Resonance Physics & Imaging (preclinical & clinical)
• Biophysics / Neurohydrodynamics
Magnetic Resonance Imaging and Engineering expertise:
• NMR, Diffusion & Flow MRI
• Brain Perfusion and Blood Brain Barrier Permeability MRI
• MRI phantom design and development for validation and multi-site harmonisation
Main biomedical applications:
• Brain tumours
• Neurovascular diseases (e.g. stroke, small vessel disease)
• Neonatal encephalopathy
Key Publications:
- Marginal diffusion slope as a prognostic imaging biomarker of infiltrating phenotype in glioblastoma; a cancer imaging biomarker roadmap study A.Vallatos, H. FI Al-Mubarak, J. L Birch, Y. Icer, C. McBain, D. Coope, K. Karabatsou, S. J Mills, G. JM Parker, W. M Holmes, A. J Chalmers, A. Jackson, A. Waldman, G. Thompson. Neuro-Oncology Advances 2026
- Gadolinium-and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease. M S Stringer, X. Shao, Hedok Lee, A. Vallatos, C. Arteaga-Reyes, U. Clancy, F. Chappell, C. Manning, M. Valdes-Hernandez, D. Jaime Garcia, R. Brown, F. N Doubal, H. Benveniste, M. J Thrippleton, D. JJ Wang, J. M Wardlaw
- 3D‐printable phantoms for quantitative dynamic contrast‐enhanced MRI. MS Sarwar, A.Vallatos, CH Lau, A Waldman, S Dimartino, MJ Thrippleton. Magnetic Resonance in Medicine. 2025.
- Quantitative multiple boli arterial spin labeling. S Paterson, A Vallatos, C Graff, WM Holmes. Magnetic Resonance Imaging. 2025
- “Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis” S. Paterson, A. Vallatos, J. Rodgers, WM Holmes. Scientific Reports 2023
- “Adaptive manufacturing for healthcare during the COVID-19 emergency and beyond”. A. Vallatos, J. M Maguire, N. Pilavakis, G. Cerniauskas, A.Sturtivant, A. J Speakman, S. Gourlay, S.Inglis, G. McCall, A.Davie, M.Boyd, A. AS Tavares et al. Front. Med. Tech. 2021
- “Stacked in-plane histology for quantitative MRI assessment: application to an infiltrative brain tumour” model“ H.F. Al-Mubarak, A. Vallatos, J.Birch, L. Gallagher, L. Gilmour, A. Chalmers, W. M. Holmes. J. Neuro. Methods. 2019
- “Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region” A. Vallatos, H. F. I. Al-Mubarak, J.Birch, L. Gallagher, L. Gilmour, W. M. Holmes and A. Chalmers. J. Magn. Res. Imaging. 2018
- “A novel small molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma” J. L. Birch, K. Strathdee, L. Gilmour, A. Vallatos, L. McDonald, A. Kouzeli, R. Vasan, A. H. Qaisi, D. R. Croft, D. Crighton, K. Gill, C. H. Gray, J. Konczal, M. Mezna, D. McArthur, A. W. Schüttelkopf, P. McConnell, M. Sime, W. M. Holmes, J. Bower, H. J. McKinnon, M. Drysdale, M. F. Olson, A. J. Chalmers. Cancer Research 2018
- “Accuracy of phase-contrast velocimetry in systems with skewed intravoxel velocity distributions” A. Vallatos, H. F. I. Al-Mubarak, J. Mullin and W. M. Holmes, J. Magn. Res. 2018
- “Multiple boli Arterial Spin Labelling for high signal-to-noise rodent brain imaging” A. Vallatos, L. Gallagher, L. Gilmour, A. Chalmers & W. M. Holmes. Magn. Res. Med. 2018
- “The effect of displacement distribution asymmetry on the accuracy of phase-shift velocimetry in porous media” Vallatos, M. N. Shukla, V. W. Phoenix and W. M. Holmes, Micropor. Mesopor. Mat. 2017
- “Accurate phase-shift velocimetry in rock” M. N. Shukla, A. Vallatos*, V. W. Phoenix and W. M. Holmes, J. Magn. Res. 2016
- “Probing composition and molecular mobility in thin spherical films using NMR measurements of diffusion” A. Vallatos, R. Kirsh, R. A. Williams, R. B. Hammond, X. D. Jia, , U. Brockel, and M. M. Britton, Ind. Eng. Chem. Res. 2015
- “Chemical patterns in translating vortices: inter- and intra-cellular mixing effects” A. Vallatos, R. D. Evans, B. W. Thompson, A. F. Taylor, and M. M. Britton, Chaos. 2013
- “Characterisation of stationary and translating vortex flow using magnetic resonance” A. Vallatos, M. C. T. Wilson, A. F. Taylor, and M. M. Britton, EuroPhys Lett. 2012