Upcoming Events

Digital Health Product Forge Feb 21, 2019 - Feb 24, 2019 — The Crags Centre, 10 Bowmont Place, Edinburgh
Professor James Boardman inaugural lecture Feb 25, 2019 05:30 PM - 06:30 PM — Lecture Theatre A, Chancellor's Building, Edinburgh, EH16 4SB
ISMRM Workshop on MR Value Mar 11, 2019 - Mar 13, 2019 — University of Edinburgh
Scotland's New Industrial Centre for AI Research in Digital Diagnostics: Vision & Opportunities in Grampian Mar 11, 2019 06:00 PM - 08:00 PM — The Rowett Institute, Ashgrove Road West, Aberdeen
Scotlands New Industrial Centre for AI Research in Digital Diagnostics: Vision & Opportunities in Glasgow Mar 14, 2019 11:30 AM - 01:30 PM — Teaching and Learning Centre, Queen Elizabeth University Hospital Glasgow

Professor David O'Hagan

Home page: Go to homepage
Position: Professor and Head of Organic Chemistry

Interests:

My research has a strong focus on organo-fluorine chemistry, and particularly organo-fluorine chemistry focused on bioorganic and chemical biology research. We are interested in the influence of the fluorine atom on the conformation and behaviour of biomolecules. We also have a strong interest in enzymatic fluorination (the fluorinase) and how that can be applied to biotechnological solutions, through molecular biology, towards the production of organisms that can produce organo-fluorine compounds by fermentation (eg. antibiotics). We have a strong interest in synthetic organic chemistry and we are focussing on the synthesis of new motifs in organo-fluorine chemistry which can be used in a variety of performance molecules.

Institute: University of St Andrews

Department: Chemistry and Centre for Biomolecular Sciences


Research Themes

Organic Fluorine chemistry, New tracers with Fluorine-18 for PET, Bioorganic chemistry

Key Publications
  • M. Winkler, J. Domarkas, L. F. Schweiger, D. O’Hagan Fluorinase coupled enzymatic base swaps generate 5'-deoxy-5'-fluoronucleosides from fluoride ion: Synthesis of [18F]-5'-deoxy-5'-fluorouridines Angew. Chemie. Int. Ed., 2008, 47, 10141 - 10143.
  • M. Onega, J. Domarkas, H. Deng, L. F. Schweiger, T. A. D. Smith, A. E. Welch, C. Plisson, A. D. Gee, D. O’Hagan. An enzymatic route to 5-deoxy-5-[18F]-fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging. Chem. Commun., 2010, 139 - 141.
  • M.Onega, M.Winkler, D. O'Hagan The fluorinase: A tool for the synthesis of fluorine-18 labelled sugars and nucleosides for positron emission tomography, Future. Med. Chem., 2009, 1, 865 - 873

Collaborators

John Mallard PET Centre, Aberdeen University Scotland

GSK PET Centre, Hammersmith Hospital, London United Kingdom