Upcoming Events

Molecular Imaging Workshop 2017 Nov 20, 2017 - Nov 23, 2017 — San Sebastian, Spain
TOPIM ("hot TOPics in IMaging") 2018: Imaging Metabolism Jan 21, 2018 - Jan 26, 2018 — L'Ecole de Physique des Houches, France
SINAPSE Molecular Imaging PET/SPECT focus group meeting Feb 05, 2018 10:30 AM - 04:00 PM — Carnegie Lecture Theatre (C3-05), Joseph Black Building, School of Chemistry, University of Glasgow
'Let's Talk About Health' free public lecture Feb 21, 2018 05:30 PM - 06:30 PM — Wellcome Auditorium, Queen’s Medical Research Institute, University of Edinburgh

Professor David O'Hagan

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Position: Professor and Head of Organic Chemistry

Interests:

My research has a strong focus on organo-fluorine chemistry, and particularly organo-fluorine chemistry focused on bioorganic and chemical biology research. We are interested in the influence of the fluorine atom on the conformation and behaviour of biomolecules. We also have a strong interest in enzymatic fluorination (the fluorinase) and how that can be applied to biotechnological solutions, through molecular biology, towards the production of organisms that can produce organo-fluorine compounds by fermentation (eg. antibiotics). We have a strong interest in synthetic organic chemistry and we are focussing on the synthesis of new motifs in organo-fluorine chemistry which can be used in a variety of performance molecules.

Institute: University of St Andrews

Department: Chemistry and Centre for Biomolecular Sciences


Research Themes

Organic Fluorine chemistry, New tracers with Fluorine-18 for PET, Bioorganic chemistry

Key Publications
  • M. Winkler, J. Domarkas, L. F. Schweiger, D. O’Hagan Fluorinase coupled enzymatic base swaps generate 5'-deoxy-5'-fluoronucleosides from fluoride ion: Synthesis of [18F]-5'-deoxy-5'-fluorouridines Angew. Chemie. Int. Ed., 2008, 47, 10141 - 10143.
  • M. Onega, J. Domarkas, H. Deng, L. F. Schweiger, T. A. D. Smith, A. E. Welch, C. Plisson, A. D. Gee, D. O’Hagan. An enzymatic route to 5-deoxy-5-[18F]-fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging. Chem. Commun., 2010, 139 - 141.
  • M.Onega, M.Winkler, D. O'Hagan The fluorinase: A tool for the synthesis of fluorine-18 labelled sugars and nucleosides for positron emission tomography, Future. Med. Chem., 2009, 1, 865 - 873

Collaborators

John Mallard PET Centre, Aberdeen University Scotland

GSK PET Centre, Hammersmith Hospital, London United Kingdom