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"Can It Read My Mind?" - What Do the Public and Experts Think of the Current (Mis)Uses of Neuroimaging?

Emerging applications of neuroimaging outside medicine and science have received intense public exposure through the media. Media misrepresentations can create a gulf between public and scientific understanding of the capabilities of neuroimaging and raise false expectations. To determine the extent of this effect and determine public opinions on acceptable uses and the need for regulation, we designed ...

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'Where are we now with intravenous thrombolysis for acute ischaemic stroke'?

The publication of the updated individual patient data meta-analysis of the larger randomised trials of intravenous rt-PA for acute ischaemic stroke has re-opened the debate about how the treatment should be used in routine practice, and what information can be expected to emerge in the next 2-3 years from the ongoing trials [the largest of which is the Third International Stroke Trial (IST-3)].

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'Yes' or 'No' to Routine Statins After Subarachnoid Hemorrhage to Prevent Delayed Cerebral Ischaemia, Vasospasm, and Death? A Cautionary Tale of 2 Meta-Analyses

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(2RS)-5,6 : 7,8-Dibenzobicyclo[2.2.2]octan-2-ol

The racemic form of the title secondary monoalcohol, C16H14O, forms crystals in which the molecules are linked into chains by hydrogen bonding. The chain architecture is unusual; adjacent molecules are related pseudosymmetrically, by either a pseudo-diad or a pseudo-glide plane, while alternate molecules are related exactly by a crystallographic glide plane.

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(eta(5)-Cyclopentadienyl)(N,N-dimethyldithiocarbamato-kappa S-2,S'')[eta(4)-tetrakis(trifluoromethyl)cyclobutadienyl]-molybdenum(IV)

The title complex, [Mo(C8F12)(C5H5)(C3H6NS2)], contains both a eta(4)-C-4(CF3)(4) cyclobutadienyl ligand with approximate C-4 nu local symmetry and a eta(5)-C5H5 cyclopentadienyl ring. The centroids of the rings and the S atoms of a chelating dithiocarbamate ligand de ne the pseudo-tetrahedral coordination of the Mo atom. The Mo-C(cyclobutadienyl) bond lengths [2.189 (2)-2.211 (2) angstrom] are unusually ...

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(R,S)-2-Iodo-reboxetine: Development as a novel SPECT radiotracer for imaging the noradrenaline transporter in brain

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1,1-bis(phenylsulfonyl)-1-(pyridinio)methanide

The title disulfonyl-stabilized pyridinium ylide, C5H5N+C-(SO2C6H5)(2) or C18H15NO4S2, contains a near planar NCS2 core. The structure suggests that the formal negative charge of the ylide C atom is delocalized to the S atoms rather than the N atom. Structural features of pyridinium ylides are briefly discussed.

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3,3-Diphenyl-6-(p-toluenesulfonyl)-6-aza-3-silabicyclo[3.1.0]hexane

The title compound, C23H23NO2SSi, at 100 K adopts a boat conformation which brings the CDH bond of an axial phenyl substituent into proximity [C . . .N = 3.376 (1) Angstrom] with the aziridine lone pair. The factors which favour this conformation for bicyclo[3.1.0]hexane systems are considered.

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3-fluoro-GABA enantiomers: exploring the conformation of GABA binding to GABA(A) receptors and GABA aminotransferase

The neurotransmitter GABA is the main inhibitory neurotransmitter of the CNS. It is estimated that 20-50% of all neuronal synapses are GABAergic. Distinct types of GABA receptor have been identified (GABA(A), GABA(B) and GABA(AOr) [GABA(C)]). The GABA(A) and GABA(AOr) variant found in the retina receptors (informally termed GABA(C)) are physiologically related in that they are both ligand (GABA)-gated ...

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3D MRI analysis of the lower legs of treated idiopathic congenital talipes equinovarus (clubfoot)

BACKGROUND: Idiopathic congenital talipes equinovarus (CTEV) is the commonest form of clubfoot. Its exact cause is unknown, although it is related to limb development. The aim of this study was to quantify the anatomy of the muscle, subcutaneous fat, tibia, fibula and arteries in the lower legs of teenagers and young adults with CTEV using 3D magnetic resonance imaging (MRI), and thus to ...

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