Organisation:
Department:
Interests:
Development, validation and translation of novel imaging biomarkers in brain disease
My research programme aims at streamlining imaging biomarkers to the clinics by methodically addressing the challenges at the interface between on one side MRI physics & imaging and on the other biology & medicine. My work lies at the intersection of these fields, covering the development of novel MRI modalities and applied biomarkers, and the systematic validation of both the MRI measure and the biomarker.
Research Themes:
Research fields:
• Magnetic Resonance Physics & Imaging (preclinical & clinical)
• Biophysics / Neurohydrodynamics
Magnetic Resonance Imaging and Engineering expertise:
• NMR, Diffusion & Flow MRI
• Brain Perfusion and Blood Brain Barrier Permeability MRI
• MRI phantom design and development for validation and multi-site harmonisation
Main biomedical applications:
• Brain tumours
• Neurovascular diseases (e.g. stroke, small vessel disease)
• Neonatal encephalopathy
Key Publications:
1. “Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model”. S. Quick, T. V. Procter, J. Moss, A. Lawson, S. Baker, M. Walton, M. Mohammad, W. Mungall, A. Onishi, Z. Tobola, M. Stringer, M. A. Jansen, A. Vallatos et al. Acta Neuropathologica, 2022
2. “Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse
model of Glioblastoma”. H. F. I. Al-Mubarak, A. Vallatos, L. Gallagher, J. L. Birch, A. J. Chalmers, and W. M. Holmes. Magn. Res. Im., 2022
3. “Adaptive manufacturing for healthcare during the COVID-19 emergency and beyond”. A. Vallatos, J. M Maguire, N. Pilavakis, G. Cerniauskas, A.Sturtivant, A. J Speakman, S. Gourlay, S.Inglis, G. McCall, A.Davie, M.Boyd, A. AS Tavares et al. Front. Med. Tech. 2021
2021.
4. “Impact of turbulence-induced asymmetric propagators on the accuracy of Phase-contrast Velocimetry” H. F. I. Al-Mubarak, A. Vallatos and W. M. Holmes, J. Magn. Res. 2020
5. “Stacked in-plane histology for quantitative MRI assessment: application to an infiltrative brain tumour” model“ H.F. Al-Mubarak, A. Vallatos, J.Birch, L. Gallagher, L. Gilmour, A. Chalmers, W. M. Holmes. J. Neuro. Methods. 2019
6. “Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion”. M.M.C. Arroja, E. Reid, L.A. Roy, A. Vallatos, W.M. Holmes, S.A. Nicklin, L.M. Work, C. McCabe. Scientific Reports. 2019
7. “Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region” A. Vallatos, H. F. I. Al-Mubarak, J.Birch, L. Gallagher, L. Gilmour, W. M. Holmes and A. Chalmers. J. Magn. Res. Imaging. 2018
8. “A novel small molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma” J. L. Birch, K. Strathdee, L. Gilmour, A. Vallatos, L. McDonald, A. Kouzeli, R. Vasan, A. H. Qaisi, D. R. Croft, D. Crighton, K. Gill, C. H. Gray, J. Konczal, M. Mezna, D. McArthur, A. W. Schüttelkopf, P. McConnell, M. Sime, W. M. Holmes, J. Bower, H. J. McKinnon, M. Drysdale, M. F. Olson, A. J. Chalmers, Cancer Research 2018
9. “Accuracy of phase-contrast velocimetry in systems with skewed intravoxel velocity distributions” A. Vallatos, H. F. I. Al-Mubarak, J. Mullin and W. M. Holmes, J. Magn. Res. 2018
10. “Multiple boli Arterial Spin Labelling for high signal-to-noise rodent brain imaging” A. Vallatos, L. Gallagher, L. Gilmour, A. Chalmers & W. M. Holmes. Magn. Res. Med. 2018
11. “The effect of displacement distribution asymmetry on the accuracy of phase-shift velocimetry in porous media” Vallatos, M. N. Shukla, V. W. Phoenix and W. M. Holmes, Micropor. Mesopor. Mat. 2017
12. “Accurate phase-shift velocimetry in rock” M. N. Shukla, A. Vallatos*, V. W. Phoenix and W. M. Holmes, J. Magn. Res. 2016
13. “Probing composition and mol¬¬¬ecular mobility in thin spherical films using NMR measurements of diffusion” A. Vallatos, R. Kirsh, R. A. Williams, R. B. Hammond, X. D. Jia, , U. Brockel, and M. M. Britton, Ind. Eng. Chem. Res. 2015
14. “Chemical patterns in translating vortices: inter- and intra-cellular mixing effects” A. Vallatos, R. D. Evans, B. W. Thompson, A. F. Taylor, and M. M. Britton, Chaos. 2013
15. “Characterisation of stationary and translating vortex flow using magnetic resonance” A. Vallatos, M. C. T. Wilson, A. F. Taylor, and M. M. Britton, EuroPhys Lett. 2012