Author(s)
Benjamin S. Aribisala, Maria C. Valdes Hernandez, Natalie A. Royle, Zoe Morris, Susana Munoz Maniega, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
ISBN
0938-7994
Publication year
2013
Periodical
European Radiology
Periodical Number
4
Volume
23
Pages
1084-1092
Author Address
OBJECTIVE:
Cerebral atrophy and white matter lesions (WMLs) are common in older people with common risk factors, but it is unclear if they are related. We investigated whether and to what degree they are related in deep and superficial structures using both volumetric and visual ratings.
METHODS:
The intracranial, total brain tissue (TBV), cerebrospinal fluid (CSF), ventricular superficial subarachnoid space (SSS), grey matter, normal-appearing white matter, WMLs, and combined CSF, venous sinuses and dural volumes were measured. WMLs were also rated using the Fazekas scale.
RESULTS:
Amongst 672 adults (mean age 73 ± 1 years), WMLs were associated with global brain atrophy (TBV,