Author(s)

N. H. Campbell, D. L. Smith, A. P. Reszka, S. Neidle, D. O'Hagan

ISBN

1477-0520

Publication year

2011

Periodical

Organic & Biomolecular Chemistry

Periodical Number

5

Volume

9

Pages

1328-1331

Author Address

Full version

Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analogue, and with a different binding mode involving reversal of the pyrrolidinium N+-H orientation.