Author(s)

C. Zanato, A. Testa, M. Zanda

ISBN

0022-1139

Publication year

2013

Periodical

Journal of Fluorine Chemistry

Periodical Number

Volume

155

Pages

110-117

Author Address

Zanda, M Univ Aberdeen, Kosterlitz Ctr Therapeut, Inst Med Sci, Foresterhill AB25 2ZD, Scotland Univ Aberdeen, Kosterlitz Ctr Therapeut, Inst Med Sci, Foresterhill AB25 2ZD, Scotland CNR ICRM, I-20131 Milan, Italy

Full version

Tritium-labelled fluoroazomycin arabinoside, [H-3]-FAZA, is a useful probe for the investigation of hypoxia, furthermore it is safer and easier to handle than the PET tracer [F-18]-FAZA when used in cell based assays. The only known synthesis of deuterium- and tritium-labelled FAZA was re-investigated and optimized. Then, a new and improved synthesis of [H-2]-FAZA was developed as a model process for tritium radiolabelling. This novel synthesis is expected to greatly facilitate access to [H-3]-FAZA. (C) 2013 Elsevier B.V. All rights reserved.