E. M. Sandeman, M. D. V. Hernandez, Z. Morris, M. E. Bastin, C. Murray, A. J. Gow, J. Corley, R. Henderson, I. J. Deary, J. M. Starr, J. M. Wardlaw



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PLoS One

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Author Address

Wardlaw, JM Univ Edinburgh, Brain Res Imaging Ctr, Div Clin Neurosci, Edinburgh, Midlothian, Scotland Univ Edinburgh, Brain Res Imaging Ctr, Div Clin Neurosci, Edinburgh, Midlothian, Scotland Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland Univ Edinburgh, Dept Clin Neurosci, SINAPSE Collaborat, Edinburgh, Midlothian, Scotland Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland Western Gen Hosp, Dept Med Elderly, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland

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Objectives: Incidental findings in neuroimaging occur in 3% of volunteers. Most data come from young subjects. Data on their occurrence in older subjects and their medical, lifestyle and financial consequences are lacking. We determined the prevalence and medical consequences of incidental findings found in community-dwelling older subjects on brain magnetic resonance imaging.
Design: Prospective cohort observational study.
Setting: Single centre study with input from secondary care.
Participants: Lothian Birth Cohort 1936, a study of cognitive ageing.
Main Outcome Measures: Incidental findings identified by two consultant neuroradiologists on structural brain magnetic resonance imaging at age 73 years; resulting medical referrals and interventions.
Primary and Secondary Outcome Measures: Prevalence of incidental findings by individual categories: neoplasms, cysts, vascular lesions, developmental, ear, nose or throat anomalies, by intra- and extracranial location; visual rating of white matter hyperintensities and brain atrophy.
Results: There were 281 incidental findings in 223 (32%) of 700 subjects, including 14 intra-or extracranial neoplasms (2%), 15 intracranial vascular anomalies (2%), and 137 infarcts or haemorrhages (20%). Additionally, 153 had moderate/severe deep white matter hyperintensities (22%) and 176 had cerebral atrophy at, or above, the upper limit of normal (25%) compared with a normative population template. The incidental findings were unrelated to white matter hyperintensities or atrophy; about a third of subjects had both incidental findings and moderate or severe WMH and a quarter had incidental findings and atrophy. The incidental findings resulted in one urgent and nine non-urgent referrals for further medical assessment, but ultimately in no new treatments.
Conclusions: In community-dwelling older subjects, incidental findings, including white matter hyperintensities and atrophy, were common. However, many findings were not of medical importance and, in this age group, most did not result in further assessment and none in change of treatment.