Author(s)

S. Patterson, D. O'Hagan

ISBN

0362-4803

Publication year

2002

Periodical

Journal of Labelled Compounds & Radiopharmaceuticals

Periodical Number

3

Volume

45

Pages

191-198

Author Address

Full version

A synthetic route to isotopically labelled forms of the tropane alkaloid hyoscyamine, including (RS)-[3′,3′,-H-2(2)]- (2a) and (RS)-[1′-C-13,3′,3′,-H-2(2)]- (2b) hyoscyamines, involving the reaction between phenylacetyl tropine and formaldehyde is described. The isotopically labelled products enable the metabolism of hyoscyamine to be studied in plants such as Datura stramonium. Copyright (C) 2002 John Wiley Sons, Ltd.