Author(s)
S. Patterson, D. O'Hagan
ISBN
0362-4803
Publication year
2002
Periodical
Journal of Labelled Compounds & Radiopharmaceuticals
Periodical Number
3
Volume
45
Pages
191-198
Author Address
A synthetic route to isotopically labelled forms of the tropane alkaloid hyoscyamine, including (RS)-[3′,3′,-H-2(2)]- (2a) and (RS)-[1′-C-13,3′,3′,-H-2(2)]- (2b) hyoscyamines, involving the reaction between phenylacetyl tropine and formaldehyde is described. The isotopically labelled products enable the metabolism of hyoscyamine to be studied in plants such as Datura stramonium. Copyright (C) 2002 John Wiley Sons, Ltd.