Author(s)
A. A. Cant, R. Bhalla, S. L. Pimlott, A. Sutherland
ISBN
1364-548X (Electronic)
1359-7345 (Linking)
Publication year
2012
Periodical
Chem Commun (Camb)
Periodical Number
33
Volume
48
Pages
3993-5
Author Address
WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer’s disease and iniparib, a compound used in the treatment of breast cancer.