A. A. Cant, R. Bhalla, S. L. Pimlott, A. Sutherland
1364-548X (Electronic) 1359-7345 (Linking)
Chem Commun (Camb)
WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer’s disease and iniparib, a compound used in the treatment of breast cancer.