Author(s)
A. A. Cant, S. Champion, R. Bhalla, S. L. Pimlott, A. Sutherland
ISBN
1521-3773 (Electronic)
1433-7851 (Linking)
Publication year
Periodical
Angew Chem Int Ed Engl
Periodical Number
30
Volume
52
Pages
7829-32
Author Address
WestCHEM, School of Chemistry, University of Glasgow, G12 8QQ, Glasgow, UK.
Rapid and efficient radioiodination of aryl and heteroaryl bromides has been achieved using a nickel(0)-mediated halogen-exchange reaction. This transformation gives direct access to [(123)I]- and [(125)I]-imaging agents for single photon emission computed tomography (SPECT), such as 5-[(123)I]-A85380 (see scheme, Boc = tert-butyloxycarbonyl, cod = 1,5-cyclooctadiene, TFA = trifluoroacetic acid).