Author(s)

M. E. Bastin, P. Le Roux

ISBN

0740-3194

Publication year

2002

Periodical

Magnetic Resonance in Medicine

Periodical Number

1

Volume

48

Pages

6-14

Author Address

Full version

The strong sensitivity of Carr-Purcell-Meiboom-Gill (CPMG) fast spin-echo (FSE) sequences, such as rapid acquisition with relaxation enhancement (RARE), to the phase of the prepared transverse magnetization means that artifact-free single-shot diffusion-weighted images can currently only be obtained with a 30-50% reduction in the signal-to-noise ratio (SNR). However, this phase sensitivity and signal loss can be addressed in FSE sequences that use quadratic phase modulation of the radio-frequency (RF) refocusing pulses to generate a sustained train of stable echoes. Here the first application of such a non-CPMG single-shot FSE (ssFSE) sequence to diffusion tensor MR imaging (DT-MRI) of the human brain is described. This approach provides high SNR diffusion-weighted images that have little or no susceptibility to poor B-0 magnetic field homogeneity and the strong eddy currents typically present in DT-MRI experiments. (C) 2002 Wiley-Liss, Inc.