The cognitive reserve hypothesis explains the disparity between clinical and pathological phenotypes and why, in two individuals with the same extent of neuropathology, one may be demented while the other …more
The conformation of 2-fluoro-N-(2-fluoroethyl)-propionamide 4 in the solid state indicates the influence of both a P-fluorine-amide gauche effect and an alpha-fluoroamide effect. The structure reveals the influence of two recently …more
On the basis of single crystal diffraction analyses it is shown that conversion of 13H-dibenzo(a,i)fluoren-13-one into its oxime causes distortion of the aromatic framework because of steric crowding. The oxime …more
Individuals with chronic obstructive pulmonary disease (COPD) and asthma are an important but poorly characterised group. The genetic determinants of COPD and asthma overlap have not been studied. The aim …more
BACKGROUND: As the clinical significance of chronic bronchitis among smokers without airflow obstruction is unclear, we sought to determine morbidity associated with this disorder. METHODS: We examined subjects from the …more
The management of acoustic neuromas is directed towards early diagnosis and surgical removal. The routine use of magnetic resonance imaging (MRI) has permitted the diagnosis of very small acoustic neuromas. …more
Whereas the links between eye movements and the shifts in visual attention are well established, less is known about how eye position affects the prioritization of visual space. It was …more
The incidence of subarachnoid haemorrhage (SAH) is 6-8 per 100 000 person years, peaking in the sixth decade. SAH, mostly due to rupture of an intracranial aneurysm, accounts for a …more