This study investigated regional cerebral blood flow in head-injured patients using statistical parametric mapping (SPM) to detect hypoperfusion on Tc-99m-hexamethylpropyleneamine oxime (HMPAO) SPECT scans. Methods: Acute and follow-up SPECT and …more
In order to image nAChR density in vivo in humans, [5- I-123] -iodo-3-[2(S)-2-azetidinylmethoxylpyridine ([5- I-123]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, in …more
Investigations on the effect of normal healthy ageing on the muscarinic system have shown conflicting results. Also, in vivo determination of muscarinic receptor binding has been hampered by a lack …more
Objectives The objectives of this study were to: (i) establish whether the spinocerebellar ataxia type 8 (SCA 8) expansion is associated with ataxia in Scotland; (ii) test the hypothesis that …more
Background. Spiral or helical arterial blood flow patterns have been widely observed in both animals and humans. The absence of spiral flow has been associated with carotid arterial disease. The …more
BACKGROUND: A number of surgical strategies and graft enhancements have been trialled to improve the performance of prosthetic grafts. Neointimal hyperplasia may, in part, be a normal cellular response to …more
PURPOSE: In clinical molecular imaging the interaction between antidepressant medication and SPECT ligands is a significant potential confound. This study measured nAChR availability, as determined by SPECT imaging, on and …more
Purpose: In clinical molecular imaging the interaction between antidepressant medication and SPECT ligands is a significant potential confound. This study measured nAChR availability, as determined by SPECT imaging, on and …more
The ligating properties of Me3N(+)-N(-)X trimethylammonio-stabilised nitrogen ylides have been investigated. The electron-rich nitrogen atom of the ylide can be attached to silver(I) and mercury(II), giving rise to new solids …more