Purpose: To prospectively determine the repeatability of functional magnetic resonance (MR) imaging brain activation tasks in a group of healthy older male volunteers. Materials and Methods: Local research ethics committee …more
We determined the reproducibility of GABA (gamma-aminobutyric acid) measurements using 2D J-resolved magnetic resonance spectroscopy (MRS) on a clinical 1.5T MR imaging scanner. Two-dimensional J-resolved spectra were acquired in vitro …more
This work describes a reproducibility analysis of scalar water diffusion parameters, measured within white matter tracts segmented using a probabilistic shape modelling method. In common with previously reported neighbourhood tractography …more
Objective We sought to evaluate the delays, between-centre variations in practice, and opportunity costs attributable to delays in research governance approval of clinical trials in the United Kingdom. Design Retrospective …more
Background and Purpose-Although magnesium is neuroprotective in animal stroke models, no clinical benefit was confirmed in the Intravenous Magnesium Efficacy in Stroke (IMAGES) trial of acute stroke patients. The Magnetic …more
Background Cerebral small vessel disease (lacunar stroke and cerebral white matter hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels show developmental and pathophysiological similarities to cerebral small …more
BACKGROUND: In visceral leishmaniasis (VL), retinal changes have previously been noted but not described in detail and their clinical and pathological significance are unknown. A prospective observational study was undertaken …more
The black void behind the pupil was optically impenetrable before the invention of the ophthalmoscope by von Helmholtz over 150 years ago. Advances in retinal imaging and image processing, especially …more
Background: Lacunar strokes account for 25% of ischaemic strokes, but their precise aetiology is unknown. Similarities between the retinal and cerebral small vessels mean that clarification of the exact relationship …more
For the discovery of biomarkers in the retinal vasculature it is essential to classify vessels into arteries and veins. We automatically classify retinal vessels as arteries or veins based on …more
Background and Purpose-Lacunar stroke is associated with an intrinsic cerebral small vessel disorder of unknown etiology, although possible causes include increased blood-brain barrier permeability. Retinal arterioles are similar to cerebral …more
The bis(mu -thiolato)dicobalt complex [Co2Cp2(V-SMe)(2)] (1) reacts with alkyne-cobalt complexes [Co-2(CO)(6)(mu -F3CC_=CR)] (2) to give tri- and tetranuclear cobalt cluster compounds. When R = CF3 the main product is [Co-2(CO)(4)(mu …more