The genes MBD1 and MBD2 encode methyl-CpG binding proteins that suppress transcription from methylated promoters. In contrast, CGBP encodes a protein that binds promoters containing unmethylated CpG and stimulates transcription. …more
Objective: Pyrexia is associated with poor outcome after stroke, but the temperature changes in the brain after stroke are poorly understood. We used magnetic resonance spectroscopic imaging (water-to-N-acetylaspartate frequency shift) …more
Magnetic resonance imaging (MRI) permits in vivo quantification of brain compartment volume, and has many applications in cognitive, clinical and comparative neuroscience. There are numerous approaches for obtaining a brain …more
The relaxation of 1H nuclei due to their interaction with quadrupolar 14N nuclei in gel structures is measured using fast field-cycling NMR. This phenomenon called quadrupolar dips has been reported …more
A magnetic resonance proton spectroscopic imaging (SI) technique was developed to measure regional brain temperatures in human subjects. The technique was validated in a homogeneous phantom and in four healthy …more
BACKGROUND AND PURPOSE: Tumor “size” is used internationally as a surrogate marker for overall survival when following current response assessment protocols (World Health Organization and Response Evaluation Criteria in Solid …more
Using quantitative MR imaging, values for the mean water diffusivity (), the diffusion anisotropy and the longitudinal relaxation time (TI) were measured for tumour, oedematous and normal brain in a …more
We investigated the interdependence of activity within the luminance (L + M) and opponent chromatic (L – M and S – [L + M]) postreceptoral mechanisms in mid-level and high-level …more
Complex organisms rely on experience to optimize the function of perceptual and motor systems in situations relevant to survival. It is well established that visual cues reliably paired with danger …more
Background Magnesium is neuroprotective in animal models of stroke, and findings of small clinical pilot trials suggest potential benefit in people. We aimed to test whether intravenous magnesium sulphate, given …more
Magnesium exhibits a range of neuronal and vascular actions that may ameliorate ischaemic CNS insults, including stroke. Significant neuroprotection with magnesium has been observed in different models of focal cerebral …more
Background and Purpose-A prespecified interaction analysis of the neutral Intravenous Magnesium Efficacy in Stroke ( IMAGES) trial revealed significant benefit from magnesium (Mg) in patients with noncortical stroke. Post hoc …more