Computer tomography (CT) perfusion imaging is widely used to calculate brain hemodynamic quantities such as cerebral blood flow, cerebral blood volume, and mean transit time that aid the diagnosis of …more
The Arg-Gly-Asp (RGD) tripeptide is the smallest recognition sequence for the alpha(v)beta(3) integrin receptor. A number of non-peptide analogues of the RGD linear sequence, some of them having improved pharmacological …more
The preparation of both enantiomers of 3,3,3-trifluoro-2-methylpropanoic acid by a lipase mediated kinetic resolution of the racemate is described. (C) 2004 Published by Elsevier Ltd.
The synthesis of the stereospecifically fluorinated difluoro- and trifluoro-rac-3 and rac-4 is described where the fluorine atoms are positioned adjacent/vicinal to each other and the physical characteristics of these candidate …more
Listening to the sound of silence: disfluent silent pauses in speech have consequences for listeners
Silent pauses are a common form of disfluency in speech yet little attention has been paid to them in the psycholinguistic literature. The present paper investigates the consequences of such …more
Localisation of regions of intense pleasure responses will lead to a better understanding of the reward mechanisms in the brain. Here we present a novel fMRI video paradigm designed to …more
BACKGROUND: There is very limited evidence for the efficacy of any specific therapeutic intervention in chronic, treatment refractory major depression. Thermal anterior capsulotomy (ACAPS) is a rarely performed but established …more
Purpose: To retrospectively evaluate the 10 year follow-up results in patients who had “kissing” self-expanding stent aortic bifurcation reconstruction. Methods: Forty-three patients were treated with “kissing” self-expanding stents for aortoiliac …more
Background In the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), early recurrent carotid stenosis was more common in patients assigned to endovascular treatment than it was in patients assigned …more
Objective To determine the effects of tow dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk.Design Randomised double blind placebo controlled …more
AIMS: To examine the relative and combined value of late gadolinium enhancement (LGE) and low-dose dobutamine (LDD) cardiac magnetic resonance (CMR) to predict ‘adverse remodelling’ (AR) following acute myocardial infarction …more