RATIONALE: FVC is a difficult maneuver for many patients, and forced expiratory volume in 6 seconds (FEV6) has been proposed as a surrogate for FVC for the diagnosis of chronic …more

Sighted animals extract motion information from visual scenes by processing spatiotemporal patterns of light falling on the retina. The dominant models for motion estimation exploit intensity correlations only between pairs …more

The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [F-18]-fluoride into [F-18]-5′-fluoro-5′-deoxyadenosine, [F-18]-5′-fluoro-5′-deoxyinosine and [F-18]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.

A novel preparation of sodium [F-18]-fluoroacetate is described where 5′-[F-18]-fluoro-5′ -deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [F-18]-fluoride and then oxidation to …more

Organofluorine compounds are rare in Nature, with only a handful known to be produced by some species of plant and two microorganisms. Consequently, the mechanism of enzymatic carbon-fluorine bond formation …more

Organic fluorine compounds have had a profound impact on the development of bioactives for the modern pharmaceuticals market It is estimated that up to 20% of pharmaceuticals prescribed or administered …more

In this review those fluorinated compounds which have found a role as anti-cancer agents are summarized. The emphasis is to highlight the important drugs but also to highlight the latest …more

Gonadotropin-releasing hormone (GnRH) is the central regulator of reproduction in vertebrates. GnRHs have recently been identified in protochordates and retain the conserved N- and C-terminal domains involved in receptor binding …more

Episodic memory is supported by recollection, the conscious retrieval of contextual information associated with the encoding of a stimulus. Event-Related Potential (ERP) studies of episodic memory have identified a robust …more

BACKGROUND: Focal cerebral ischaemia causes release of excitatory amino acid (EAA) neurotransmitters, principally glutamate, with resultant over-stimulation of EAA receptors and downstream pathways. Excess glutamate release is a pivotal event …more

Cognitive impairment in amyotrophic lateral sclerosis is characterized by deficits on tests of executive function; however, the contribution of abnormal processing speed is unknown. Methods are confounded by tasks that …more

The dopamine system has been linked to anhedonia in depression and both the positive and negative symptoms of schizophrenia, but it remains unclear how dopamine dysfunction could mechanistically relate to …more