A. J. Murray, J. F. Sauer, G. Riedel, C. McClure, L. Ansel, L. Cheyne, M. Bartos, W. Wisden, P. Wulff
1546-1726 (Electronic) 1097-6256 (Linking)
Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.
Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.