Author(s)

A. J. Murray, J. F. Sauer, G. Riedel, C. McClure, L. Ansel, L. Cheyne, M. Bartos, W. Wisden, P. Wulff

ISBN

1546-1726 (Electronic) 1097-6256 (Linking)

Publication year

2011

Periodical

Nat Neurosci

Periodical Number

3

Volume

14

Pages

297-9

Author Address

Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.

Full version

Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.