Author(s)
D. O'Hagan
ISBN
0022-1139
Publication year
2006
Periodical
Journal of Fluorine Chemistry
Periodical Number
11
Volume
127
Pages
1479-1483
Author Address
This is a summary of a lecture presented at the 100th Anniversary, Moissan Symposium in Paris on Friday, 10 November 2006. The lecture highlighted recent developments on the enzyme structure, mechanism and biotransformation prospects of the fluorinase enzyme identified in 2002 from the bacterium Streptomyces cattleya. Over-expression of the enzyme has allowed it to be used as a catalyst for F-18-incorporation during the synthesis of potential ligands for positron emission tomography (PET) applications. (c) 2006 Elsevier B.V. All rights reserved.