Author(s)
A. Ratkevicius, A. Joyson, I. Selmer, T. Dhanani, C. Grierson, A. M. Tommasi, A. DeVries, P. Rauchhaus, D. Crowther, S. Alesci, P. Yaworsky, F. Gilbert, T. W. Redpath, J. Brady, K. C. Fearon, D. M. Reid, C. A. Greig, H. Wackerhage
ISBN
1758-535X (Electronic)
1079-5006 (Linking)
Publication year
2011
Periodical
J Gerontol A Biol Sci Med Sci
Periodical Number
6
Volume
66
Pages
620-6
Author Address
School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 +/- 2 years; 266 +/- 54 N/m; 8,686 +/- 1,154 mm(2)) than in mildly sarcopenic (69 +/- 3 years; 183 +/- 17 N/m; 6,621+/-718 mm(2)) and severely sarcopenic men (76 +/- 6 years; 127 +/- 23 N/m; 5,846 +/- 591 mm(2)), respectively (p