Author(s)
P. Kocienski, R. Narquizian, P. Raubo, C. Smith, L. J. Farrugia, K. Muir, F. T. Boyle
ISBN
1470-4358
Publication year
2000
Periodical
Journal of the Chemical Society-Perkin Transactions 1
Periodical Number
15
Volume
Pages
2357-2384
Author Address
A general modular approach to the members of the pederin family of antitumour agents is exemplified by syntheses of mycalamide B and theopederin D as well as a formal synthesis of pederin. All three compounds are prepared from 6-lithio-2,3-dimethyl-4-phenylselenomethyl-3,4-dihydro-2H-pyran and 2-(3-chloropropyl)-3,3-dimethyl-3,4-dihydro-2H-pyran-4-one.