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SINAPSE Image of the Month: 18F-Fluorination

June 2016 SINAPSE Image of the Month

June2016

Courtesy of Prof David O’Hagan, this image shows the fluorinase enzyme catalysing 18F-Fluorination of a dendrimeric PGD peptide for radiochemical imaging.

The study was recently published in Organic & Biomolecular Chemistry:

Thompson S, Fleming IN, O'Hagan D. Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase Organic & Biomolecular Chemistry 2016; 14:3120-9.