UK PET Chemistry Workshop on Radiotracer Dispensing Oct 21, 2022 09:00 AM - 05:00 PM — KCL, London
Scottish Radiotherapy Research Forum Nov 10, 2022 10:00 AM - 04:00 PM — University of Stirling
IPEM Advanced Neuro MRI Nov 15, 2022 09:00 AM - 05:00 PM — Birmingham


SINAPSE experts from around Scotland have developed ten online modules designed to explain medical imaging. They are freely available and are intended for non-specialists. **Unfortunately these do not currently work in browsers**

Edinburgh Imaging Academy at the University of Edinburgh offers the following online programmes through a virtual learning environment:

Neuroimaging for Research MSc/Dip/Cert

Imaging MSc/Dip/Cert

PET-MR Principles & Applications Cert

Applied Medical Image Analysis Cert

Online Short Courses

SINAPSE Image of the Month: MR-PET differentiation of cardiac amyloid subtypes

November 2020 SINAPSE Image of the Month


Courtesy of Dr Jack Andrews and Prof Marc Dweck, this image shows late gadolinium-enhanced (LGE) cardiac MR images [top row] and corresponding fused 18F-fluoride cardiac MR-PET images [bottom row] comparing radiotracer uptake patterns across four cohorts of study participants in columns from left to right: Age and sex matched controls, patients with aortic stenosis, and patients with cardiac amyloid of two subtypes: amyloid light chain (AL) and amyloidosis transthyretin (ATTR).

Gadolinium-enhanced MR is widely used to diagnose cardiac amyloid, but cannot differentiate AL and ATTR subtypes which are associated with different prognoses and different treatment strategies. A single MR-PET scan enables the accurate diagnosis of cardiac amyloid from MR with clear discrimination of AL and TTR amyloid from 18F-fluoride PET in co-registered images. The mean target to background ratio (TBR) values in the image above demonstrate uptake greater in the blood pool than myocardium for a control subject (E) and a patient with aortic stenosis (F), contrasted with an AL amyloid patient displaying a characteristic distribution of myocardial LGE (C) and patchy myocardial uptake greater than the blood pool (G) whereas a TTR amyloid patient displaying similar LGE findings (D) is distinguished by extensive biventricular uptake (H). These findings show promise for 18F-fluoride cardiac MR-PET imaging in the diagnosis and monitoring of patients with TTR amyloid.


The image is taken from a recently published multicentre study that conducted hybrid 18F-fluoride imaging with participants recruited in Edinburgh and New York, notably one of the first publications of data from the first MR PET system in Scotland (opened in 2017 at Edinburgh Imaging Facility QMRI):

Andrews JPM, Trivieri MG, Everett R, Spath N, MacNaught G, Moss AJ, Doris MK, Pawade T, van Beek EJR, Lucatelli C, Newby DE, Robson P, Fayad ZA, Dweck MR. 18F-fluoride PET/MR in cardiac amyloid: A comparison study with aortic stenosis and age- and sex-matched controls. J Nucl Cardiol 2020.