Background: [Methyl-H-3]-choline is a promising new positron emission tomography (PET) agent used for cancer imaging whose mechanism has still not fully been elucidated. In this study, whether [methyl-H-3]-choline determined by …more
Purpose: The aim of the study was to investigate the intracellular location of [methyl-H-3]choline in MCF7 tumour cells and to determine the relationship between [methyl-H-3]choline incorporation and proliferation. Methods: Tumour …more
We have previously performed quantitative kinetic modeling of [I-123] CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, …more
The bis(nitrile) complex [Mo2Cp2(mu-SMe)(3)(NCCH3)(2)]( BF4) (1) reacts with HCtCCPh(2)(OH) to give the mu-alkyne product [Mo2Cp2(mu-SMe)(3) {HC CCPh2(OH)}](BF4) (2). Sequential treatment with triethylamine and tetrafluoroboric acid converts 2 almost quantitatively, Via …more
Recent improvements in MR image acquisition and post-processing techniques have allowed quantitative kidney volume measurements to be derived from patient studies. These morphological indices can provide “snapshot” assessments that may …more
We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 x 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 mu m high-voltage CMOS technology …more
Computers may have the potential to augment human cognitive processes in ways that could be beneficial for people with dementia. This possibility is being investigated by a multidisciplinary team. Previous …more
The purposes of this study were: to describe chest CT findings in normal non-smoking controls and cigarette smokers with and without COPD; to compare the prevalence of CT abnormalities with …more
Background. A wide range of neuropsychiatric conditions, including schizophrenia and autistic spectrum disorder (ASD), are associated with impairments in social function. Previous studies have shown that individuals with schizophrenia and …more
CIRCA lets those with short-term memory loss draw on reminiscences to converse with relatives and caregivers. The system, which software engineers, psychologists, and designers developed with caregiver input, features a …more
Spatiotemporally structured noise, such as physiological noise, is a potential source of artifacts in functional magnetic resonance imaging (fMRI) and is the main limiting factor for the detection of small …more
DFT derived conformational energy profiles of a series of beta-substituted alpha-fluoroethanes (F-CH2CH2-X) have been explored where the substituent X was varied as NH3+, OCOH, NCO, NO2, NHCHO, F, N-3, CH=NH, …more